Epithelial Mesenchymal Transition in Embryonic Development, Tissue Repair and Cancer: A Comprehensive Overview.
Epithelial Mesenchymal Transition in Embryonic Development, Tissue Repair and Cancer: A Comprehensive Overview.
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DOI：
10.3390/jcm7010001
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发表时间：
2017-12-22
影响因子：
3.9
通讯作者：
Chen YH
中科院分区：
文献类型：
--
作者：
Kim DH;Xing T;Yang Z;Dudek R;Lu Q;Chen YH
上皮间质转化（EMT）在正常生理事件（例如胚胎发育）和异常病理事件（例如肿瘤形成和转移）中发挥着核心作用。胚胎发育中发生的过程通常在肿瘤发生等病理条件下重新激活。因此，定义胚胎发育过程中 EMT 所涉及的调控网络（基因和蛋白质水平）对于理解肿瘤发育和转移所涉及的调控网络至关重要。 EMT过程涉及许多分子、因子、介质和信号通路。虽然 EMT 是一个非常古老的话题，有大量的出版物，但最近的新技术和发现给这个研究领域带来了一些新的视角和方向。现在很清楚，除了放大初始信号的转录后和翻译后修饰之外，这些重要过程还受到转录和翻译调节因子网络的控制。在这篇综述文章中，我们将讨论 EMT 研究领域的一些关键概念、历史发现以及最新进展。
The epithelial mesenchymal transition (EMT) plays a central role in both normal physiological events (e.g., embryonic development) and abnormal pathological events (e.g., tumor formation and metastasis). The processes that occur in embryonic development are often reactivated under pathological conditions such as oncogenesis. Therefore, defining the regulatory networks (both gene and protein levels) involved in the EMT during embryonic development will be fundamental in understanding the regulatory networks involved in tumor development, as well as metastasis. There are many molecules, factors, mediators and signaling pathways that are involved in the EMT process. Although the EMT is a very old topic with numerous publications, recent new technologies and discoveries give this research area some new perspective and direction. It is now clear that these important processes are controlled by a network of transcriptional and translational regulators in addition to post-transcriptional and post-translational modifications that amplify the initial signals. In this review article, we will discuss some key concepts, historical findings, as well as some recent progresses in the EMT research field.
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影响因子：
11.2
作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1073/pnas.1102454108
发表时间：
2011-05-10
影响因子：
11.1
作者：
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