Distinct representations of olfactory information in different cortical centres.
Distinct representations of olfactory information in different cortical centres.
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DOI：
10.1038/nature09868
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发表时间：
2011-04-14
期刊：
影响因子：
64.8
通讯作者：
Datta, Sandeep Robert
中科院分区：
文献类型：
--
作者：
Sosulski, Dara L.;Bloom, Maria Lissitsyna;Cutforth, Tyler;Axel, Richard;Datta, Sandeep Robert
感官信息被传输到大脑，必须在大脑中进行处理，将刺激特征转化为适当的行为输出。在嗅觉系统中，鼻子中的分布式神经活动被转换成嗅球中的隔离图。在这项研究中，我们询问这种有序表征如何在高级嗅觉中心中转化。我们开发了一种追踪策略来定义将信息从嗅球中的单个肾小球传递到梨状皮层和皮质杏仁核的神经回路。球茎中的空间秩序在梨状皮层中被丢弃；来自单个肾小球的轴突广泛地投射到梨状体，没有明显的空间偏好。在皮质杏仁核中，我们观察到大片的投影，这些投影是针对单个肾小球进行空间定型的。这些对杏仁核的投影是重叠的，并为来自多个肾小球的信息的空间局部整合提供了机会。梨状体投射的分布模式和杏仁核投射的刻板化模式的识别为习得和先天行为的生成提供了解剖学背景。
Sensory information is transmitted to the brain where it must be processed to translate stimulus features into appropriate behavioral output. In the olfactory system, distributed neural activity in the nose is converted into a segregated map in the olfactory bulb. In this study we ask how this ordered representation is transformed in higher olfactory centers. We have developed a tracing strategy to define the neural circuits that convey information from individual glomeruli in the olfactory bulb to the piriform cortex and the cortical amygdala. The spatial order in the bulb is discarded in piriform cortex; axons from individual glomeruli project diffusely to the piriform without apparent spatial preference. In the cortical amygdala, we observe broad patches of projections that are spatially stereotyped for individual glomeruli. These projections to the amygdala are overlapping and afford the opportunity for spatially localized integration of information from multiple glomeruli. The identification of a distributive pattern of projections to the piriform and stereotyped projections to the amygdala provides an anatomic context for the generation of learned and innate behaviors.
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