Which environments matter in studies of early life developmental plasticity?
Which environments matter in studies of early life developmental plasticity?
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DOI：
10.1093/emph/eox024
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Kuzawa CW
中科院分区：
文献类型：
--
作者：
Kuzawa CW
在《》一书中，英国流行病学家大卫·巴克和他的同事们[1]报告了来自英国的耐人寻味的发现：出生时身材瘦小的人罹患心脏病的风险最高。这与关于营养和体重在心血管疾病中的作用的传统观点背道而驰，后者被经典地视为“过度疾病”。对动物模型的研究很快证实，限制向胎儿输送营养物质会导致类似的成人疾病后果。这项工作毫无疑问地表明，妊娠营养和其他产前因素会影响一个人患上许多慢性退行性疾病的风险，这迫使他们重新思考其根本原因。对于专注于进化领域的研究人员来说，早期营养不良会增加一个人患与成人超重有关的疾病的风险，这一发现看起来像是发育可塑性出了问题[2]：该发现表明，营养设置点可能会根据孕妇在子宫中的营养输送进行校准，如果未来的环境突然改变，这可能会适得其反，就像席卷全球大部分地区的快速生活方式和饮食变化所发生的那样。贝特森[3]将这种影响描述为类似于母亲发送‘天气预报’，这个概念后来被更名为更一般的‘预测性适应反应’[4]。
In 1989, the British epidemiologist David Barker and his colleagues [1] reported intriguing findings from the UK showing that risk for heart disease was highest among people who were born small and thin. This ran counter to conventional wisdom regarding the role of nutrition and weight in cardiovascular diseases, which were classically viewed as ‘diseases of excess’. Research on animal models soon confirmed that restricting nutrient delivery to the fetus induces a similar constellation of adult disease outcomes. This work left little doubt that gestational nutrition and other prenatal factors influence one’s risk for developing many chronic degenerative diseases, which forced a rethink of their fundamental causes.To researchers in evolutionarily focused fields, the finding that early life undernutrition heightens one’s risk for diseases related to adult overweight looked like developmental plasticity gone awry [2]: the findings suggested that nutrient set points might be calibrated to maternal nutrient delivery in utero and that this could then backfire if future environments changed abruptly, as is occurring with the rapid lifestyle and dietary changes that are sweeping much of the globe. Bateson [3] described such effects as akin to the mother sending a ‘weather forecast’, a concept later rebranded in the more general concept of a ‘predictive adaptive response’[4].
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影响因子：
2.9
作者：
Chung, Green C.;Kuzawa, Christopher W.
通讯作者：
Kuzawa, Christopher W.
影响因子：
3.8
作者：
Kuzawa, Christopher W.;Thayer, Zaneta M.
通讯作者：
Thayer, Zaneta M.
影响因子：
7.1
作者：
Behrman, Jere R.;Calderon, Maria C.;Stein, Aryeh D.
通讯作者：
Stein, Aryeh D.
影响因子：
2.9
作者：
Kuzawa, CW
通讯作者：
Kuzawa, CW
影响因子：
105.7
作者：
BARKER, DJP;OSMOND, C;WADSWORTH, MEJ
通讯作者：
WADSWORTH, MEJ