Prediction of CCND1 amplification using plasma DNA as a prognostic marker in oesophageal squamous cell carcinoma.
Prediction of CCND1 amplification using plasma DNA as a prognostic marker in oesophageal squamous cell carcinoma.
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DOI：
10.1038/sj.bjc.6605657
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发表时间：
2010-04-27
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
We aimed to develop a new biomarker to predict cyclin D1 (CCND1) status using plasma DNA in oesophageal squamous cell carcinoma (ESCC) patients. We evaluated the ratio of the CCND1 (11q13) dosage to the dopamine receptor D2 (DRD2; 11q22-23) dosage (C/D ratio) as CCND1 copy number. This study was divided into three steps: (1) Determination of a cutoff value for the C/D ratio in test scale; (2) Comparison of the C/D ratio in between plasma samples and cancer tissues in ESCC patients showing high plasma C/D ratio; (3) Validation study of the clinical application of the plasma C/D ratio as a diagnostic and prognostic marker, by comparing with clinicopathologic factors in 96 ESCC patients. The plasma C/D ratio was significantly higher in the ESCC group than the controls (P=0.0134). A high plasma C/D ratio reflected the tumour C/D ratio, and significantly correlated with a poorer prognosis (P=0.0186). Moreover, the high C/D ratio was found to be an independent prognostic factor on multivariate analysis (P=0.0266; hazard ratio 5.988). Prediction of CCND1 amplification using plasma DNA is thought to be a promising prognostic biomarker in ESCC patients.
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影响因子：
2.5
作者：
Koike, H;Ichikawa, D;Yamagishi, H
通讯作者：
Yamagishi, H
影响因子：
3.8
作者：
Sato-Kuwabara Y;Neves JI;Fregnani JH;Sallum RA;Soares FA
通讯作者：
Soares FA
DOI：
10.1073/pnas.87.24.9958
发表时间：
1990-12-01
影响因子：
11.1
作者：
HOLLSTEIN, MC;METCALF, RA;HARRIS, CC
通讯作者：
HARRIS, CC
影响因子：
8.8
作者：
通讯作者：
--
影响因子：
6.8
作者：
Park, Kyoung Un;Lee, Hee Eun;Lee, Hye Seung
通讯作者：
Lee, Hye Seung