Neuron deficit in the white matter and subplate in periventricular leukomalacia.
Neuron deficit in the white matter and subplate in periventricular leukomalacia.
复制标题
DOI：
10.1002/ana.22612
复制
发表时间：
2012-03
影响因子：
11.2
通讯作者：
Volpe, Joseph J.
中科院分区：
文献类型：
--
作者：
Kinney, Hannah C.;Haynes, Robin L.;Xu, Gang;Andiman, Sarah E.;Folkerth, Rebecca D.;Sleeper, Lynn A.;Volpe, Joseph J.
早产儿脑室周围白质软化症（PVL）认知异常的细胞基础尚不确定。一个重要的可能性是，对大脑皮层形成至关重要的白色物质和亚板神经元的损伤与PVL中的少突胶质细胞和轴突损伤一起发生。我们检验了这样一个假设，即与非PVL对照组相比，PVL病例中白色物质和亚板区的神经元总密度显著降低。我们使用了一种基于计算机的方法来测定PVL病例和对照组的脑室/脑室下区、脑室周围白色物质、中央白色物质和亚板区的MAP 2免疫标记神经元的密度。皮质下神经元有五种亚型：颗粒、单极、双极、倒锥体和多极。PVL病例（n=15）中四个区域中每个区域的颗粒神经元的神经元密度比调整年龄和死后间隔的对照组（n=10）低54-80%（p≤0.01）。单极，双极，多极和倒锥体神经元的整体密度没有显着差异PVL的情况下和对照组之间。没有颗粒神经元表达神经元和神经胶质不成熟的标志物（Tuj 1，doublecortin，或NG 1）。这些数据表明，敏感颗粒神经元的定量赤字发生在远离室周病灶的白色物质中，包括板下区域，在PVL，并可能导致异常皮质形成和认知功能障碍早产儿幸存者。
The cellular basis of cognitive abnormalities in preterm infants with periventricular leukomalacia (PVL) is uncertain. One important possibility is that damage to white matter and subplate neurons which are critical to the formation of the cerebral cortex occurs in conjunction with oligodendrocyte and axonal injury in PVL. We tested the hypothesis that the overall density of neurons in the white matter and subplate region is significantly lower in PVL cases compared to non-PVL controls. We used a computer-based method for the determination of the density of MAP2-immunolabeled neurons in the ventricular/subventricular region, periventricular white matter, central white matter, and subplate region in PVL cases and controls. There were five subtypes of subcortical neurons: granular, unipolar, bipolar, inverted pyramidal, and multipolar. The neuronal density of the granular neurons in each of the four regions was 54–80% lower (p≤0.01) in the PVL cases (n=15) compared to controls adjusted for age and postmortem interval (n=10). The overall densities of unipolar, bipolar, multipolar, and inverted pyramidal neurons did not differ significantly between the PVL cases and controls. No granular neurons expressed markers of neuronal and glial immaturity (Tuj1, doublecortin, or NG1). These data suggest that quantitative deficits in susceptible granular neurons occur in the white matter distant from periventricular foci, including the subplate region, in PVL, and may contribute to abnormal cortical formation and cognitive dysfunction in preterm survivors.
登录
查看更多内容
影响因子：
12.7
作者：
Kadhim, H;Tabarki, B;Sébire, G
通讯作者：
Sébire, G
影响因子：
2.5
作者：
Garcia-Marin, V.;Blazquez-Llorca, L.;DeFelipe, J.
通讯作者：
DeFelipe, J.
影响因子：
64.8
作者：
GHOSH, A;ANTONINI, A;SHATZ, CJ
通讯作者：
SHATZ, CJ
影响因子：
6.4
作者：
Billiards, Saraid S.;Haynes, Robin L.;Kinney, Hannah C.
通讯作者：
Kinney, Hannah C.
影响因子：
2.5
作者：
KOSTOVIC, I;RAKIC, P
通讯作者：
RAKIC, P