Cytonemes and the dispersion of morphogens.

Cytonemes and the dispersion of morphogens.
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DOI:
10.1002/wdev.151
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发表时间:
2014-11
影响因子:
--
通讯作者:
Kornberg, Thomas B.
Kornberg, Thomas B.
中科院分区:
生物学2区
文献类型:
--
作者:
Kornberg, Thomas B.

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丝状足是细胞突起,与许多类型的机械感觉活动有关。形态因子是调节胚胎和组织发育模式的信号蛋白。两者都有很长的历史,可以追溯到20世纪早期细胞和发育生物学的开始,但最近的发现将称为细胞素的特殊丝状足与形态因子运动和形态因子信号传导联系起来。这篇综述探讨了旁分泌信号传导模型的概念和实验背景,在该模型中,细胞之间的形态因子交换被定向到细胞素直接将产生形态因子的细胞与接收和响应它们的细胞联系起来的位点。
Filopodia are cellular protrusions that have been implicated in many types of mechanosensory activities. Morphogens are signaling proteins that regulate the patterned development of embryos and tissues. Both have long histories that date to the beginnings of cell and developmental biology in the early 20th century, but recent findings tie specialized filopodia called cytonemes to morphogen movement and morphogen signaling. This review explores the conceptual and experimental background for a model of paracrine signaling in which the exchange of morphogens between cells is directed to sites where cytonemes directly link cells that produce morphogens to cells that receive and respond to them.
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