Cytonemes and the dispersion of morphogens.
Cytonemes and the dispersion of morphogens.
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DOI:
10.1002/wdev.151
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发表时间:
2014-11
影响因子:
--
通讯作者:
Kornberg, Thomas B.
中科院分区:
文献类型:
--
作者:
Kornberg, Thomas B.
Filopodia are cellular protrusions that have been implicated in many types of mechanosensory activities. Morphogens are signaling proteins that regulate the patterned development of embryos and tissues. Both have long histories that date to the beginnings of cell and developmental biology in the early 20th century, but recent findings tie specialized filopodia called cytonemes to morphogen movement and morphogen signaling. This review explores the conceptual and experimental background for a model of paracrine signaling in which the exchange of morphogens between cells is directed to sites where cytonemes directly link cells that produce morphogens to cells that receive and respond to them.
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