Hippocampal volume changes across developmental periods in female migraineurs.
Hippocampal volume changes across developmental periods in female migraineurs.
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DOI：
10.1016/j.ynpai.2023.100137
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发表时间：
2023-08
期刊：
影响因子：
--
通讯作者：
Borsook, David
中科院分区：
文献类型：
--
作者：
Wilcox, Sophie L.;Nelson, Sarah;Ludwick, Allison;Youssef, Andrew M.;Lebel, Alyssa;Beccera, Lino;Burstein, Rami;Borsook, David
主要目的是确定女性偏头痛患者的海马结构在不同发育阶段是否存在差异。结果表明偏头痛和年龄可能与海马体积有交互关系。研究结果表明，海马可塑性可能反映了偏头痛的成分，随着寿命的变化。大脑相关的可塑性可以发生在一个显着的速度不同的发展时期。特别是青春期已被确定为神经系统结构和功能的生长和变化时期。值得注意的是，研究已经确定偏头痛在儿童和成人人群中都很常见，但有证据表明，由于每个发育阶段的独特需求，偏头痛的表型可能在这些队列中有所不同。因此，本研究的主要目的是定义患有和不患有偏头痛的女性（7-27岁）的海马结构，并确定这在发育阶段是否不同（即，儿童期、青少年期和青年期）。使用FMRIB的集成配准和分割工具基于高分辨率结构MRI量化海马体积。结果表明，偏头痛和年龄可能与海马体积有一个相互关系，这样，虽然海马体积较低的女性偏头痛患者（与年龄匹配的对照组相比）在儿童期和青春期，这种对比不同，在青年期，海马体积较高的偏头痛患者（与年龄匹配的对照组相比）。随后的顶点分析将这种相互作用效应定位于海马体积中的前海马位移。偏头痛患者青少年发育期间海马体积的转变表明，海马可塑性可能动态地反映了偏头痛的组成部分，这些组成部分在生命周期中发生变化，对偏头痛发作相关的压力产生可能的改变反应，从而产生生理表达和心理社会影响。
Primary aims were to determine whether hippocampal structure differs across developmental stages in female migraineurs. Results indicated that migraine and age may have an interactional relationship with hippocampal volume. Findings suggest that hippocampal plasticity may reflect components of migraine that change over the lifespan. Brain-related plasticity can occur at a significant rate varying on the developmental period. Adolescence in particular has been identified as a period of growth and change across the structure and function of the nervous system. Notably, research has identified migraines as common in both pediatric and adult populations, but evidence suggests that the phenotype for migraines may differ in these cohorts due to the unique needs of each developmental period. Accordingly, primary aims of this study were to define hippocampal structure in females (7–27 years of age) with and without migraine, and to determine whether this differs across developmental stages (i.e., childhood, adolescence, and young adulthood). Hippocampal volume was quantified based on high-resolution structural MRI using FMRIB's Integrated Registration and Segmentation Tool. Results indicated that migraine and age may have an interactional relationship with hippocampal volume, such that, while hippocampal volumes were lower in female migraineurs (compared to age-matched controls) during childhood and adolescence, this contrast differed during young adulthood whereby hippocampal volumes were higher in migraineurs (compared to age-matched controls). Subsequent vertex analysis localized this interaction effect in hippocampal volume to displacement of the anterior hippocampus. The transition of hippocampal volume during adolescent development in migraineurs suggests that hippocampal plasticity may dynamically reflect components of migraine that change over the lifespan, exerting possible altered responsivity to stress related to migraine attacks thus having physiological expression and psychosocial impact.
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