Impact of lysosome status on extracellular vesicle content and release.
Impact of lysosome status on extracellular vesicle content and release.
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溶酶体状态对细胞外囊泡含量和释放的影响。
DOI：
10.1016/j.arr.2016.05.001
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发表时间：
2016-12
影响因子：
13.1
通讯作者：
Mattson, Mark P.
中科院分区：
文献类型：
--
作者：
Eitan, Erez;Suire, Caitlin;Zhang, Shi;Mattson, Mark P.
细胞外囊泡（EV）是从细胞释放的纳米尺寸的气泡状膜结构。EV含有RNA、脂质和蛋白质，被认为具有多种作用，包括细胞间通讯和去除错误折叠的蛋白质。EV中错误折叠和聚集的蛋白质的分泌可能是自噬-溶酶体和泛素-蛋白酶体途径的货物处置替代方案。在这篇综述中，我们将讨论的重要性，溶酶体功能的调节EV分泌和内容。外泌体是通过多泡体（MVB）与质膜融合而释放的EV的亚型。MVB也可以与溶酶体融合，因此MVB的运输途径可以决定外泌体是否从细胞中释放。在这里，我们总结了溶酶体抑制对EV分泌的影响的研究数据，以及细胞通过处理EV中潜在的有毒物质来补偿溶酶体功能障碍的可能性。更好地理解调节MVB向溶酶体和质膜运输的分子机制可以促进对致病蛋白质、脂质或感染因子在细胞内或细胞外积累的疾病的理解。
Extracellular vesicles (EVs) are nanoscale size bubble-like membranous structures released from cells. EVs contain RNA, lipids and proteins and are thought to serve various roles including intercellular communication and removal of misfolded proteins. The secretion of misfolded and aggregated proteins in EVs may be a cargo disposal alternative to the autophagy-lysosomal and ubiquitin-proteasome pathways. In this review we will discuss the importance of lysosome functionality for the regulation of EV secretion and content. Exosomes are a subtype of EVs that are released by the fusion of multivesicular bodies (MVB) with the plasma membrane. MVBs can also fuse with lysosomes, and the trafficking pathway of MVBs can therefore determine whether or not exosomes are released from cells. Here we summarize data from studies of the effects of lysosome inhibition on the secretion of EVs and on the possibility that cells compensate for lysosome malfunction by disposal of potentially toxic cargos in EVs. A better understanding of the molecular mechanisms that regulate trafficking of MVBs to lysosomes and the plasma membrane may advance an understanding of diseases in which pathogenic proteins, lipids or infectious agents accumulate within or outside of cells.
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DOI：
10.1111/tra.12016
发表时间：
2013-01
期刊：
Traffic (Copenhagen, Denmark)
影响因子：
--
作者：
Beckett K;Monier S;Palmer L;Alexandre C;Green H;Bonneil E;Raposo G;Thibault P;Le Borgne R;Vincent JP
通讯作者：
Vincent JP
影响因子：
15.1
作者：
Danzer KM;Kranich LR;Ruf WP;Cagsal-Getkin O;Winslow AR;Zhu L;Vanderburg CR;McLean PJ
通讯作者：
McLean PJ
DOI：
10.1007/s00018-014-1764-3
发表时间：
2015-02
期刊：
Cellular and molecular life sciences : CMLS
影响因子：
--
作者：
Brinton LT;Sloane HS;Kester M;Kelly KA
通讯作者：
Kelly KA
影响因子：
7.3
作者：
Andreu Z;Yáñez-Mó M
通讯作者：
Yáñez-Mó M
影响因子：
4
作者：
Colombo, Marina;Moita, Catarina;Raposo, Graca
通讯作者：
Raposo, Graca