Generalized vibratory deficits in osteoarthritis of the hip.
Generalized vibratory deficits in osteoarthritis of the hip.
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DOI：
10.1002/art.24004
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发表时间：
2008-09-15
影响因子：
--
通讯作者：
Block, Joel A.
中科院分区：
文献类型：
--
作者：
Shakoor, Najia;Lee, Kristen J.;Fogg, Louis F.;Block, Joel A.
膝骨关节炎 (OA) 患者存在下肢感觉缺陷，包括本体感觉、关节运动觉和最近的振动感减弱。然而，先前尚未评估过髋关节骨关节炎的类似缺陷。振动知觉阈值 (VPT) 是用于评估感觉缺陷的可靠测量方法，并且适合测试多个身体部位。本研究检查了患有髋部 OA 的受试者与未患有髋部 OA 的受试者上肢和下肢的 VPT。将 14 名有症状和影像学髋关节 OA 的受试者与 13 名年龄匹配的无髋关节 OA 的对照者进行比较。使用生物感觉计评估 VPT。对 OA 和对照受试者下肢的 5 个部位和上肢的 1 个部位（桡骨头）进行评估和比较。与对照组相比，OA 受试者的所有 6 个测试点的 VPT 均显着降低（所有点的 P < 0.05）。 OA 受试者和对照组的 VPT 评分（平均值 ± SEM 伏特）如下：第一跖趾关节（13.5 ± 1.4 对比 7.4 ± 0.7）、内踝（18.1 ± 2.6 对比 11.2 ± 1.7）、外踝（20.9 ± 2.4 对比 10.6 ± 1.5）、股骨内侧髁（22.8 ± 2.9 对比 12.6 ± 1.3）、股骨外侧髁（26.7 ± 2.6 对比 16.2 ± 1.9）和桡骨头（10.2 ± 0.8 对比 7.5 ± 0.6）。据我们所知，这是第一项评估髋部骨关节炎感觉缺陷的研究，并证明与对照组相比，这些受试者的上肢和下肢都存在振动感丧失。所指出的普遍缺陷可能对 OA 的神经机械病理生理学产生重大影响。
Lower extremity sensory deficits, including reduced proprioception, joint kinesthesia, and, recently, vibratory sense, have been described in subjects with osteoarthritis (OA) of the knee. However, comparable deficits in OA of the hip have not previously been evaluated. Vibratory perception threshold (VPT) is a reliable measure used to assess sensory deficits and is amenable to testing multiple body sites. This study examined VPT at the upper and lower extremities of subjects with hip OA compared with subjects without hip OA. Fourteen subjects with symptomatic and radiographic hip OA were compared with 13 age-matched controls without hip OA. VPT was assessed using a biothesiometer. Five sites in the lower extremity and 1 site in the upper extremity (radial head) were evaluated and compared between OA and control subjects. VPT was significantly reduced at all 6 testing sites of the OA subjects compared with controls (P < 0.05 for all sites). VPT scores (mean ± SEM volts) for OA subjects and controls were as follows: first metatarsophalangeal joint (13.5 ± 1.4 versus 7.4 ± 0.7), medial malleolus (18.1 ± 2.6 versus 11.2 ± 1.7), lateral malleolus (20.9 ± 2.4 versus 10.6 ± 1.5), medial femoral condyle (22.8 ± 2.9 versus 12.6 ± 1.3), lateral femoral condyle (26.7 ± 2.6 versus 16.2 ± 1.9), and radial head (10.2 ± 0.8 versus 7.5 ± 0.6). To our knowledge, this is the first study to evaluate sensory deficits in hip OA and to demonstrate that there is vibratory sense loss at both the upper and lower extremities in these subjects compared with controls. The noted generalized deficits may have significant implications in the neuromechanical pathophysiology of OA.
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影响因子：
--
作者：
Pai, YC;Rymer, WZ;Sharma, L
通讯作者：
Sharma, L
影响因子：
3.5
作者：
van Deursen, RWM;Sanchez, MM;Cavanagh, PR
通讯作者：
Cavanagh, PR
DOI：
10.1007/bf00236057
发表时间：
1990-12-01
期刊：
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY AND OCCUPATIONAL PHYSIOLOGY
影响因子：
--
作者：
FRENETTE, B;MERGLER, D;FERRARIS, J
通讯作者：
FERRARIS, J
DOI：
10.1002/art.23241
发表时间：
2008-01-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Shakoor, Najia;Agrawal, Alan;Block, Joel A.
通讯作者：
Block, Joel A.
影响因子：
2.3
作者：
Sharma, L
通讯作者：
Sharma, L