Selenium intake help prevent age-related cataract formation: Evidence from NHANES 2001-2008.
Selenium intake help prevent age-related cataract formation: Evidence from NHANES 2001-2008.
复制标题
硒摄入量有助于预防年龄相关性白内障的形成：来自NHANES 2001-2008年的证据。
DOI：
10.3389/fnut.2023.1042893
复制
发表时间：
2023
影响因子：
5
通讯作者：
Yu, Ziyan
中科院分区：
文献类型：
--
作者：
Xu, Baiwei;Liu, Zhongwei;Zhao, Jiangyue;Yu, Ziyan
关键词：
白内障是致盲和视力障碍的主要原因之一，全世界约有1600万人。微量元素在人体的多种生理过程中起着重要的作用。本研究的目的是根据2001-2008年国家健康和营养调查（NHANES）的数据，调查每日膳食微量元素摄入量与年龄相关性白内障发病率之间的关系。本研究在50岁及以上的非裔美国人和55岁及以上的美国成人受试者中进行了铁、锌、铜和硒研究。采用多因素Logistic回归分析，探讨微量元素摄入量与白内障发病的关系。筛选后，7，525例受试者最终入选本研究。多元Logistic回归分析显示硒摄入量与白内障发病率呈显著负相关模型1：OR = 0.998，95%CI = 0.997-1.000;模型2：OR = 0.997，95%CI = 0.995-1.000;模型3：OR = 0.998，95%CI = 0.995-1.000）。在将硒摄入量分成五分位数后，在模型3的第一个五分位数、所有模型的第四个五分位数和第五个五分位数中观察到硒摄入量与白内障之间的显著负相关。在调整了年龄和性别的亚组分析中，仅在65-74岁的女性中观察到显著的负相关。我们的研究指出，维持较高水平的每日膳食硒摄入量有助于预防白内障，增加65-74岁美国妇女每日膳食硒摄入量可能有助于预防年龄相关性白内障。铁、锌、铜的摄入量可能与年龄相关性白内障无关。
Cataract is one of the leading causes of blindness and visual impairment, about 16 million people around the world. Trace elements play an important role in a variety of the processes in human body. This study aimed to investigate the association between daily dietary intake of trace elements and age-related cataract incidence based on data from the National Health and Nutrition Examination Survey (NHANES) 2001–2008. Iron, zinc, copper, and selenium were conducted in this study among subjects aged 50 years and older for African Americans and 55 and older in US adults. Multivariate logistic regression analysis was used in different models to investigate the association of trace elements intake and cataract. After screening, 7,525 subjects were ultimately included in this study. A significant negative association was found between selenium intake and cataract incidence in adjusted models using multivariate logistic regression analysis (model 1: OR = 0.998, 95% CI = 0.997–1.000; model 2: OR = 0.997, 95% CI = 0.995–1.000; and model 3: OR = 0.998, 95% CI = 0.995–1.000). After dividing selenium intake into quintiles, significant negative associations between selenium intake and cataract were observed in the first quintile of model 3, the fourth and fifth quintiles of all models. In subgroup analyses adjusted for age and sex, a significant negative association was observed only in women aged 65–74 years. Our study points out that maintaining daily dietary selenium intake at higher levels is helpful for cataract prevention, and that increasing daily dietary selenium intake in American women aged 65–74 years may contribute to the prevention of age-related cataract. The intakes of iron, zinc, copper may not be associated with age-related cataract.
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DOI：
10.1126/science.abo3959
发表时间：
2022-03-18
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Kahlson, Martha A;Dixon, Scott J
通讯作者：
Dixon, Scott J
影响因子：
2
作者：
HUANG, LL;HESS, JL;BUNCE, GE
通讯作者：
BUNCE, GE
影响因子：
3.9
作者：
Dawczynski, J;Blum, M;Strobel, J
通讯作者：
Strobel, J
影响因子：
--
作者：
GLYNN, RJ;CHRISTEN, WG;HENNEKENS, CH
通讯作者：
HENNEKENS, CH
影响因子：
3.5
作者：
Baecker, Tanja;Mangus, Katharina;Grabrucker, Andreas M.
通讯作者：
Grabrucker, Andreas M.