Altered brain activation during response inhibition in obstructive sleep apnea.
Altered brain activation during response inhibition in obstructive sleep apnea.
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DOI：
10.1111/j.1365-2869.2008.00707.x
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发表时间：
2009-06
影响因子：
4.4
通讯作者：
Drummond SP
中科院分区：
文献类型：
--
作者：
Ayalon L;Ancoli-Israel S;Drummond SP
本研究探讨了阻塞性睡眠呼吸暂停（OSA）患者在Go-NoGo任务中的反应抑制。对14例OSA患者和14例正常对照者进行了功能磁共振成像（FMRI）研究。与对照组相比，OSA组在NoGo试验期间显示出更多的假阳性（委托错误），左中央后回、扣带回和顶叶下叶以及右丘脑和壳核的大脑激活减少。这与先前的研究结果一致，即OSA患者在工作记忆任务期间表现受损和大脑激活减少，这表明响应认知挑战的脑功能受损可能是OSA患者中观察到的一些认知缺陷的基础。
This study examined response inhibition during a Go-NoGo task in individuals with obstructive sleep apnea (OSA). Fourteen OSA patients and 14 controls were studied with functional magnetic resonance imaging (FMRI). Compared to Controls, the OSA group showed more false positives (error of commission) during the NoGo trials with decreased brain activation in the left postcentral gyrus, cingulate gyrus, and inferior parietal lobe, as well as right insula and putamen. This is consistent with previous findings of impaired performance and decreased brain activation in OSA patients during a working memory task, suggesting that compromised brain function in response to cognitive challenges may underlie some of the cognitive deficits seen in patients with OSA.
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影响因子：
5.7
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作者：
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