Quantitative contributions of diet and liver synthesis to docosahexaenoic acid homeostasis.
Quantitative contributions of diet and liver synthesis to docosahexaenoic acid homeostasis.
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DOI：
10.1016/j.plefa.2010.02.015
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发表时间：
2010-04
期刊：
影响因子：
--
通讯作者：
Gao F
中科院分区：
文献类型：
--
作者：
Rapoport SI;Igarashi M;Gao F
Dietary requirements for maintaining brain and heart docosahexaenoic acid (DHA, 22:6n-3) homeostasis are not agreed on, in part because rates of liver DHA synthesis from circulating α-linolenic acid (α-LNA, 18:2n-3) have not been quantified. These rates can be estimated in vivo using intravenous radiotracer- or heavy isotope-labeled α-LNA infusion. In adult unanesthetized male rats, such infusion shows that liver synthesis-secretion rates of DHA from α-LNA markedly exceed brain and heart DHA synthesis rates and brain DHA consumption rate, and that liver but not heart or brain synthesis is upregulated as dietary n-3 PUFA content is reduced. These differences in rate reflect much higher expression of DHA-synthesizing enzymes in liver, and upregulation of liver but not heart or brain enzyme expression by reduced dietary n-3 PUFA content. A noninvasive intravenous [U-13C]α-LNA infusion method that produces steady-state liver tracer metabolism gives exact liver DHA synthesis-secretion rates and could be extended for human studies.
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影响因子：
6.5
作者：
Gao, Fei;Kiesewetter, Dale;Igarashi, Miki
通讯作者：
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影响因子：
4.2
作者：
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通讯作者：
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Hill, Alison M.
影响因子：
4.2
作者：
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影响因子：
6.5
作者：
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通讯作者：
Rapoport, Stanley I.