Electro-acupuncture improves the social interaction behavior of rats
Electro-acupuncture improves the social interaction behavior of rats
复制标题
电针改善大鼠的社交行为
DOI：
10.1016/j.physbeh.2015.08.014
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发表时间：
2015-11
影响因子：
2.9
通讯作者：
Han, Ji-Sheng
中科院分区：
文献类型：
--
作者：
Xu, Xin-Jie;Han, Song-Ping;Zhang, Rong;Han, Ji-Sheng
催产素（OXT）和精氨酸加压素（AVP）是两种密切相关的神经肽，参与哺乳动物社会行为的调节。本实验室的一项临床研究表明，电针可减轻孤独症儿童的社会功能障碍，并伴有外周OXT和AVP水平的变化。然而，目前尚不清楚EA刺激是否对中枢OXT和AVP水平有影响。在本研究中，大鼠进行了单次会议的EA（sEA）或重复会议的EA（rEA）。在刺激后，测定OXT/AVP系统的mRNA水平和肽水平。结果表明，sEA可诱导下丘脑OXT和AVP mRNA表达的区域特异性上调，而对下丘脑和外周血中OXT和AVP含量无影响。对低社会互动（LSI）大鼠进行9天5次的rEA。接受rEA的LSI大鼠表现出显著的社会行为改善，其特征在于在三室社交性测试中花费更多的时间来研究陌生大鼠。社交能力的改善伴随着下丘脑SON中OXT或AVP的mRNA和肽水平的上调以及血清AVP水平的显著升高。结论：电针刺激引起的亲社会效应可能与OXT/AVP系统的激活有关。
Oxytocin (OXT) and arginine-vasopressin (AVP) are two closely related neuropeptides and implicated in the regulation of mammalian social behaviors. A prior clinical study in our laboratory suggested that electro-acupuncture (EA) alleviated social impairment in autistic children accompanied by changes of peripheral levels of OXT and AVP. However, it remains unclear whether EA stimulation had an impact on central OXT and AVP levels. In the present study, rats were subjected to a single session of EA (sEA) or repeated sessions of EA (rEA). Following the stimulation, mRNA levels and peptide levels of OXT/AVP systems were determined. The results showed that sEA led to region-specific up-regulation of OXT and AVP mRNA levels in the hypothalamus where the peptides were produced, without affecting the content of OXT and AVP in the hypothalamus and peripheral blood. The rEA of 5 sessions in 9 days was given to the low socially interacting (LSI) rats. LSI rats that underwent rEA showed significant improvement of social behavior characterized by spending more time investigating the strange rats in the three-chamber sociability test. The improved sociability was accompanied by an up-regulation of mRNA and the peptide levels of OXT or AVP in SON of the hypothalamus as well as a significant increase of the serum level of AVP. It is concluded that activation of OXT/AVP systems may be associated with the pro-social effect caused by EA stimulation.
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DOI：
10.1155/2013/404956
发表时间：
2013
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Zhang H;Chen X;Zhang C;Zhang R;Lao L;Wan Y;Yi M
通讯作者：
Yi M
影响因子：
3
作者：
Jun Yang;Yu Yang;Cheng-hai Wang;Gen Wang;Hong-tao Xu;Wen-yan Liu;Bao-cheng Lin
通讯作者：
Jun Yang;Yu Yang;Cheng-hai Wang;Gen Wang;Hong-tao Xu;Wen-yan Liu;Bao-cheng Lin
影响因子：
5.3
作者：
Hurlemann, Rene;Patin, Alexandra;Kendrick, Keith M.
通讯作者：
Kendrick, Keith M.
影响因子：
3.7
作者：
Linnet Ramos;Callum Hicks;Alex Caminer;I. McGregor
通讯作者：
Linnet Ramos;Callum Hicks;Alex Caminer;I. McGregor
DOI：
10.1073/pnas.81.7.2006
发表时间：
1984-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
IVELL, R;RICHTER, D
通讯作者：
RICHTER, D