Comparison of electroacupuncture in restrained and unrestrained rat models.
Comparison of electroacupuncture in restrained and unrestrained rat models.
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DOI：
10.1155/2013/404956
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Yi M
中科院分区：
文献类型：
--
作者：
Zhang H;Chen X;Zhang C;Zhang R;Lao L;Wan Y;Yi M
针灸和电针（EA）被广泛用于治疗包括疼痛在内的各种疾病。在临床前研究中，EA通常通过将针灸针插入限制在小管或袋中的大鼠的后肢来应用。这种电针抑制模式不仅导致应激样行为，而且刺激部位和强度也受到限制。2004年，一种新颖的、无限制的EA模型被引入。然而，这两种EA方法从未直接比较过它们的镇痛效果和其他特征，如压力。在本研究中，我们报告了限制性和非限制性电针对大鼠足底注射CFA引起的急性炎性疼痛的镇痛作用相似。此外，接受无限制EA的大鼠表现出不太明显的应激样行为和耐受较高的电流强度。这些优点表明，这种无限制的电针方法可以取代传统的限制程序，具有类似的镇痛效果，并允许更多的刺激强度和位置的选择。
Acupuncture and electroacupuncture (EA) are widely used to treat a variety of diseases including pain. In preclinical research, EA is usually applied by inserting acupuncture needles into the hindlimbs of rats restrained in small tubes or bags. This restrained model of EA not only causes stress-like behaviors but also is limited in stimulating locations and intensities. In 2004, a novel, unrestrained model of EA was introduced. However, these two EA methods have never been directly compared regarding their analgesic effects and other features such as stress. In the present study, we reported similar analgesic effects between restrained and unrestrained EA in rats of acute inflammatory pain induced by intraplantar injection of CFA. In addition, rats receiving unrestrained EA showed less significant stress-like behaviors and tolerated higher current intensity. These advantages suggest that this unrestrained EA method can replace the traditional restrained procedure with similar analgesic effects and allow for more choices of stimulating intensities and locations.
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