Breakup and then makeup: a predictive model of how cilia self-regulate hardness for posture control.
Breakup and then makeup: a predictive model of how cilia self-regulate hardness for posture control.
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DOI：
10.1038/srep01956
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发表时间：
2013
影响因子：
4.6
通讯作者：
Hansen, Joshua C.
中科院分区：
文献类型：
--
作者：
Bandyopadhyay, Promode R.;Hansen, Joshua C.
作为传感器和推进器，纤毛是进化上保守的细胞器，具有高度组织化的内部结构。草履虫的纤毛如何在其回程中产生偏离推进平面的曲率，以达到对称破缺和减阻的目的尚不清楚。我们解释这些纤毛变形通过开发一个扭摆模型的拍频依赖粘度和橄榄小脑模型的自我调节的姿态控制。确定了纤毛扭转的相位依赖性，并提供了具有预测功能的硬度控制的生物物理模型。在动力冲程期间，中央微管对之间的横桥连接使纤毛变硬;该冲程的结束是一个关键阶段，在此期间ATP分子在纤毛拐点处软化横桥微管附着，其中扭转最大。硬度的急剧下降，标志着ATP水解的开始，使纤毛重新变硬。纤毛吸引盆可作为扰动传感的参考。
Functioning as sensors and propulsors, cilia are evolutionarily conserved organelles having a highly organized internal structure. How a paramecium's cilium produces off-propulsion-plane curvature during its return stroke for symmetry breaking and drag reduction is not known. We explain these cilium deformations by developing a torsional pendulum model of beat frequency dependence on viscosity and an olivo-cerebellar model of self-regulation of posture control. The phase dependence of cilia torsion is determined, and a bio-physical model of hardness control with predictive features is offered. Crossbridge links between the central microtubule pair harden the cilium during the power stroke; this stroke's end is a critical phase during which ATP molecules soften the crossbridge-microtubule attachment at the cilium inflection point where torsion is at its maximum. A precipitous reduction in hardness ensues, signaling the start of ATP hydrolysis that re-hardens the cilium. The cilium attractor basin could be used as reference for perturbation sensing.
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DOI：
10.1083/jcb.78.2.451
发表时间：
1978-08
期刊：
The Journal of cell biology
影响因子：
--
作者：
Dute R;Kung C
通讯作者：
Kung C
影响因子：
2
作者：
Dillon, RH;Fauci, LJ
通讯作者：
Fauci, LJ
DOI：
10.1073/pnas.94.12.6001
发表时间：
1997-06-10
影响因子：
11.1
作者：
Gueron, S;LevitGurevich, K;Blum, JJ
通讯作者：
Blum, JJ
影响因子：
5.5
作者：
LLINAS, R;YAROM, Y
通讯作者：
YAROM, Y
影响因子：
4.6
作者：
Bandyopadhyay, Promode R.;Leinhos, Henry A.
通讯作者：
Leinhos, Henry A.