The gut microbiome: Relationships with disease and opportunities for therapy.
The gut microbiome: Relationships with disease and opportunities for therapy.
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DOI：
10.1084/jem.20180448
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发表时间：
2019-01-07
期刊：
影响因子：
--
通讯作者：
Lynch SV
中科院分区：
文献类型：
--
作者：
Durack J;Lynch SV
本文综述了肠道微生物群对宿主健康的影响，重点是免疫调节，并讨论了控制肠道微生物群以管理或预防慢性炎症性疾病的策略。在过去的十年里，我们对与人类相关的微生物的看法已经超越了几个物种的观点，开始欣赏在人类宿主中随着年龄的增长而发展起来的多样化和利基专业化的微生物群落。最大的微生物储存库存在于远端胃肠道，在管腔中，微生物促进初级和次级新陈代谢，并在粘膜表面，它们在那里与宿主免疫细胞群相互作用。虽然肠道局部微生物驱动的免疫调节被很好地描述，但最近的研究表明，肠道微生物群在影响远处器官以及粘膜和造血免疫功能方面发挥了作用。因此，毫不奇怪，肠道微生物区系的组成和功能的扰动与从胃肠道炎症和代谢疾病到神经、心血管和呼吸系统疾病的慢性疾病有关。目前相当大的努力集中在从健康结果的角度理解人类微生物组发育的自然历史，同时提高我们对微生物组-宿主分子相互作用的了解。这些努力的最终目的是开发有效的方法来恢复受干扰的人类微生物生态系统，以此作为恢复健康或预防疾病的手段。该综述详细介绍了肠道微生物群在调节宿主健康中的作用，重点是免疫调节，并讨论了操纵肠道微生物群以管理或预防慢性炎症状况的策略。
This review provides an overview of the influence of the gut microbiome on host health with a focus on immunomodulation and discusses strategies for manipulating the gut microbiome for the management or prevention of chronic inflammatory conditions. Over the past decade, our view of human-associated microbes has expanded beyond that of a few species toward an appreciation of the diverse and niche-specialized microbial communities that develop in the human host with chronological age. The largest reservoir of microbes exists in the distal gastrointestinal tract, both in the lumen, where microbes facilitate primary and secondary metabolism, and on mucosal surfaces, where they interact with host immune cell populations. While local microbial-driven immunomodulation in the gut is well described, more recent studies have demonstrated a role for the gut microbiome in influencing remote organs and mucosal and hematopoietic immune function. Unsurprisingly, therefore, perturbation to the composition and function of the gut microbiota has been associated with chronic diseases ranging from gastrointestinal inflammatory and metabolic conditions to neurological, cardiovascular, and respiratory illnesses. Considerable effort is currently focused on understanding the natural history of microbiome development in humans in the context of health outcomes, in parallel with improving our knowledge of microbiome–host molecular interactions. These efforts ultimately aim to develop effective approaches to rehabilitate perturbed human microbial ecosystems as a means to restore health or prevent disease. This review details the role of the gut microbiome in modulating host health with a focus on immunomodulation and discusses strategies for manipulating the gut microbiome for the management or prevention of chronic inflammatory conditions.
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影响因子：
11.1
作者：
Amar, Jacques;Chabo, Chantal;Waget, Aurelie;Klopp, Pascale;Vachoux, Christelle;Bermudez-Humaran, Luis G.;Smirnova, Natalia;Berge, Mathieu;Sulpice, Thierry;Lahtinen, Sampo;Ouwehand, Arthur;Langella, Philippe;Rautonen, Nina;Sansonetti, Philippe J.;Burcelin, Remy
通讯作者：
Burcelin, Remy
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K
影响因子：
8
作者：
Cait, A.;Hughes, M. R.;Mohn, W. W.
通讯作者：
Mohn, W. W.
影响因子：
64.5
作者：
Brodin P;Jojic V;Gao T;Bhattacharya S;Angel CJ;Furman D;Shen-Orr S;Dekker CL;Swan GE;Butte AJ;Maecker HT;Davis MM
通讯作者：
Davis MM
影响因子：
17.1
作者：
Arrieta, Marie-Claire;Stiemsma, Leah T.;Finlay, B. Brett
通讯作者：
Finlay, B. Brett