Fructus Ligustri Lucidi in Osteoporosis: A Review of its Pharmacology, Phytochemistry, Pharmacokinetics and Safety.
Fructus Ligustri Lucidi in Osteoporosis: A Review of its Pharmacology, Phytochemistry, Pharmacokinetics and Safety.
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DOI：
10.3390/molecules22091469
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发表时间：
2017-09-05
期刊：
影响因子：
--
通讯作者：
Zhang D
中科院分区：
文献类型：
--
作者：
Chen B;Wang L;Li L;Zhu R;Liu H;Liu C;Ma R;Jia Q;Zhao D;Niu J;Fu M;Gao S;Zhang D
背景：女贞子作为防治骨质疏松症的一种替代药物，已受到越来越多的关注。本研究旨在综述黄连对骨质疏松症作用的传统解释、主要植物化学成分、药代动力学、改善骨质作用的药理作用和安全性。材料与方法：应用计算机检索PubMed、中国国家知识基础设施、国家科学技术图书馆、中国科技期刊数据库、Web of Science等数据库，检索与FLL相关的文献。初步查询摘要中是否存在下列关键词组合：女贞子、骨质疏松、植物化学、药代动力学、药理学、成骨细胞、破骨细胞、红景天苷。研究人员查阅了约150篇研究论文和综述。结果：中药扶正口服液具有改善肝肾两虚、减轻腰背酸痛的抗骨质疏松作用。动物和细胞实验数据表明，黄连口服液通过调节甲状旁腺激素/成纤维细胞生长因子23/1，25-(OH)2D3/CaSR、NOX4/ROS/NF-κB和OPG/RANKL/组织蛋白K信号通路，改善去卵巢、生长期、老年和糖尿病大鼠的骨代谢和骨质量。目前已从该植物中分离出100多个化合物。齐墩果酸、熊果酸、红景天苷和牛至内酯已被报道具有抗骨质疏松的作用。药代动力学数据表明，红景天苷是其有效成分之一，在生理条件下很难检测到酪醇。急性和亚急性毒性研究表明，FLL耐受性良好，不存在安全问题。结论：黄连为预防和治疗骨质疏松症提供了一种新的选择，人们对从该植物中寻找潜在的抗骨质疏松化合物和部位越来越感兴趣。关于其骨骼保护效果和安全性的精心设计的临床试验有望提供更多的科学证据。
Background: Fructus Ligustri Lucidi (FLL) has now attracted increasing attention as an alternative medicine in the prevention and treatment of osteoporosis. This study aimed to provide a general review of traditional interpretation of the actions of FLL in osteoporosis, main phytochemical constituents, pharmacokinetics, pharmacology in bone improving effect, and safety. Materials and Methods: Several databases, including PubMed, China National Knowledge Infrastructure, National Science and Technology Library, China Science and Technology Journal Database, and Web of Science were consulted to locate publications pertaining to FLL. The initial inquiry was conducted for the presence of the following keywords combinations in the abstracts: Fructus Ligustri Lucidi, osteoporosis, phytochemistry, pharmacokinetics, pharmacology, osteoblasts, osteoclasts, salidroside. About 150 research papers and reviews were consulted. Results: FLL is assumed to exhibit anti-osteoporotic effects by improving liver and kidney deficiencies and reducing lower back soreness in Traditional Chinese Medicine (TCM). The data from animal and cell experiments demonstrate that FLL is able to improve bone metabolism and bone quality in ovariectomized, growing, aged and diabetic rats through the regulation of PTH/FGF-23/1,25-(OH)2D3/CaSR, Nox4/ROS/NF-κB, and OPG/RANKL/cathepsin K signaling pathways. More than 100 individual compounds have been isolated from this plant. Oleanolic acid, ursolic acid, salidroside, and nuzhenide have been reported to exhibit the anti-osteoporosis effect. The pharmacokinetics data reveals that salidroside is one of the active constituents, and that tyrosol is hard to detect under physiological conditions. Acute and subacute toxicity studies show that FLL is well tolerated and presents no safety concerns. Conclusions: FLL provides a new option for the prevention and treatment of osteoporosis, which attracts rising interests in identifying potential anti-osteoporotic compounds and fractions from this plant. Further scientific evidences are expected from well-designed clinical trials on its bone protective effects and safety.
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影响因子：
2.9
作者：
Gao Zhen;Lu Yong;Xu Dan
通讯作者：
Xu Dan
影响因子：
4.1
作者：
Fleet JC
通讯作者：
Fleet JC
影响因子：
4.2
作者：
Brown, Alex J.;Ritter, Cynthia S.
通讯作者：
Ritter, Cynthia S.
影响因子：
3.6
作者：
Chau, TS;Lai, WP;Wong, MS
通讯作者：
Wong, MS
影响因子：
4
作者：
Conigrave AD
通讯作者：
Conigrave AD