Towards the Rational Design of Ionic Liquid Matrices for Secondary Ion Mass Spectrometry: Role of the Anion
Towards the Rational Design of Ionic Liquid Matrices for Secondary Ion Mass Spectrometry: Role of the Anion
复制标题
用于二次离子质谱分析的离子液体基质的合理设计：阴离子的作用
DOI：
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发表时间：
2013
影响因子：
3.2
通讯作者：
A. Walker
中科院分区：
文献类型：
--
作者：
Jennifer J Dertinger;A. Walker
摘要离子液体（IL）阴离子结构对分析物信号增强的作用已被系统地研究在二次离子质谱（西姆斯）使用各种样品，包括脂质，甾醇，聚合物和肽。合成了24种离子液体。12种基质酸均为肉桂酸衍生物。使用两种碱：1-甲基咪唑和三丙胺。三种基质，甲基咪唑邻香豆酸盐，三丙基铵邻香豆酸盐，和三丙基铵3，4，5-三甲氧基肉桂酸盐，是“通用”的矩阵，提高所有测试的分析物。基质酸的pKa似乎对分析物离子强度没有强烈影响。相反，观察到阴离子芳环上的单个羟基导致分子离子强度显著增加。对于芳环上存在的-CH 3、-CF 3和-OCH 3基团，未观察到分析物信号增强。芳环上的-OH基团的位置也改变分子离子强度增强。以及取代基的化学特性和位置，芳环上的部分的数量可能会影响观察到的分析物信号增强。这些观察结果表明IL阴离子芳环的活化对于优化分析物信号强度是重要的。西姆斯成像的复杂结构，如生物样品的影响，进行了讨论。
AbstractThe role of the ionic liquid (IL) anion structure on analyte signal enhancements has been systematically investigated in secondary ion mass spectrometry (SIMS) using a variety of samples, including lipids, sterols, polymers, and peptides. Twenty-four ILs were synthesized. The 12 matrix acids were cinnamic acid derivatives. Two bases were employed: 1-methylimidazole and tripropylamine. Three matrices, methylimmidazolium o-coumarate, tripropylammonium o-coumarate, and tripropylammonium 3,4,5-trimethoxycinnamate, were “universal” matrices enhancing all analytes tested. The pKa of the matrix acid does not appear to have a strong effect on analyte ion intensities. Rather, it is observed that a single hydroxyl group on the anion aromatic ring leads to significantly increased molecular ion intensities. No analyte signal enhancements were observed for –CH3, –CF3 and –OCH3 groups present on the aromatic ring. The position of the –OH group on the aromatic ring also alters molecular ion intensity enhancements. As well as the chemical identity and position of substituents, the number of moieties on the aromatic ring may affect the analyte signal enhancements observed. These observations suggest that the activation of the IL anion aromatic ring is important for optimizing analyte signal intensities. The implications for SIMS imaging of complex structures, such as biological samples, are discussed.
影响因子：
2
作者：
Carda-Broch, S;Berthod, A;Armstrong, DW
通讯作者：
Armstrong, DW
影响因子：
7.4
作者：
Armstrong, DW;Zhang, LK;Gross, ML
通讯作者：
Gross, ML
影响因子：
7.4
作者：
Laremore, Tatiana N.;Zhang, Fuming;Linhardt, Robert J.
通讯作者：
Linhardt, Robert J.