Geographical variations in sex ratio trends over time in multiple sclerosis.
Geographical variations in sex ratio trends over time in multiple sclerosis.
复制标题
DOI：
10.1371/journal.pone.0048078
复制
发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
MSBase Study Group and the New Zealand MS Prevalence Study Group
中科院分区：
文献类型：
--
作者：
Trojano M;Lucchese G;Graziano G;Taylor BV;Simpson S Jr;Lepore V;Grand'maison F;Duquette P;Izquierdo G;Grammond P;Amato MP;Bergamaschi R;Giuliani G;Boz C;Hupperts R;Van Pesch V;Lechner-Scott J;Cristiano E;Fiol M;Oreja-Guevara C;Saladino ML;Verheul F;Slee M;Paolicelli D;Tortorella C;D'Onghia M;Iaffaldano P;Direnzo V;Butzkueven H;MSBase Study Group and the New Zealand MS Prevalence Study Group
A female/male (F/M) ratio increase over time in multiple sclerosis (MS) patients was demonstrated in many countries around the world. So far, a direct comparison of sex ratio time-trends among MS populations from different geographical areas was not carried out. In this paper we assessed and compared sex ratio trends, over a 60-year span, in MS populations belonging to different latitudinal areas. Data of a cohort of 15,996 (F = 11,290; M = 4,706) definite MS with birth years ranging from 1930 to 1989 were extracted from the international MSBase registry and the New Zealand MS database. Gender ratios were calculated by six decades based on year of birth and were adjusted for the F/M born-alive ratio derived from the respective national registries of births. Adjusted sex ratios showed a significant increase from the first to the last decade in the whole MS sample (from 2.35 to 2.73; p = 0.03) and in the subgroups belonging to the areas between 83° N and 45° N (from 1.93 to 4.55; p<0.0001) and between 45° N to 35° N (from 1.46 to 2.30; p<0.05) latitude, while a sex ratio stability over time was found in the subgroup from areas between 12° S and 55° S latitude. The sex ratio increase mainly affected relapsing-remitting (RR) MS. Our results confirm a general sex ratio increase over time in RRMS and also demonstrate a latitudinal gradient of this increase. These findings add useful information for planning case-control studies aimed to explore sex-related factors responsible for MS development.
登录
查看更多内容
影响因子：
11.2
作者：
McDonald, WI;Compston, A;Wolinsky, JS
通讯作者：
Wolinsky, JS
影响因子：
9.9
作者：
Islam, Talat;Gauderman, W. James;Mack, Thomas M.
通讯作者：
Mack, Thomas M.
影响因子：
5.8
作者：
Kragt, J. J.;van Amerongen, B. M.;Lips, P.
通讯作者：
Lips, P.
影响因子：
9.9
作者：
Marrie, RA;Cutter, G;Vollmer, T
通讯作者：
Vollmer, T
影响因子：
5.8
作者：
Debouverie, M.;Pittion-Vouyovitch, S.;Guillemin, F.
通讯作者：
Guillemin, F.