Rabbit M1 and M2 macrophages can be induced by human recombinant GM-CSF and M-CSF.
Rabbit M1 and M2 macrophages can be induced by human recombinant GM-CSF and M-CSF.
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DOI：
10.1002/2211-5463.12101
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发表时间：
2016-09
期刊：
影响因子：
2.6
通讯作者：
Leung, Kai-Poon
中科院分区：
文献类型：
--
作者：
Yamane, Kazuyoshi;Leung, Kai-Poon
大型真菌可以改变其表型，以响应环境线索。极化的巨噬细胞大致分为两组：经典活化的M1和交替活化的M2。人巨噬细胞的特性已被广泛研究，但在兔子极化的巨噬细胞还没有得到表征。我们表征了使用人重组GM-CSF和M-CSF极化的兔巨噬细胞。GM-CSF处理的巨噬细胞的促炎细胞因子（M1表型）的mRNA表达高于M-CSF处理的对应物。相比之下，在M-CSF处理的巨噬细胞中发现高水平的TGF-β和IL-10表达（M2表型）。本研究有助于了解极化巨噬细胞在兔疾病模型中的作用。
Macrophages can change their phenotype in response to environmental cues. Polarized macrophages are broadly classified into two groups: classical activated M1 and alternative activated M2. Characterization of human macrophages has been widely studied, but polarized macrophages in rabbits have not been characterized. We characterized rabbit macrophages that were polarized using human recombinant GM‐CSF and M‐CSF. GM‐CSF‐treated macrophages had higher mRNA expression of proinflammatory cytokines (M1 phenotype) than did the M‐CSF‐treated counterpart. By contrast, high levels of TGF‐β and IL‐10 expression (M2 phenotype) were found in M‐CSF‐treated macrophages. The present study may be useful to understand roles of polarized macrophages in rabbit disease models.
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