Clinical factors associated with high-risk carotid plaque features as assessed by magnetic resonance imaging in patients with established vascular disease (from the AIM-HIGH Study).
Clinical factors associated with high-risk carotid plaque features as assessed by magnetic resonance imaging in patients with established vascular disease (from the AIM-HIGH Study).
复制标题
通过磁共振成像评估了已建立血管疾病的患者（来自AIM-HIGH研究），与高风险的颈动脉斑块特征相关的临床因素。
DOI：
10.1016/j.amjcard.2014.08.001
复制
发表时间：
2014-11-01
影响因子：
2.8
通讯作者：
Yuan, Chun
中科院分区：
文献类型：
--
作者：
Zhao, Xue-Qiao;Hatsukami, Thomas S.;Hippe, Daniel S.;Sun, Jie;Balu, Niranjan;Isquith, Daniel A.;Crouse, John R., III;Anderson, Todd;Huston, John, III;Polissar, Nayak;O'Brien, Kevin;Yuan, Chun
临床因素与高危斑块特征（如帽薄或破裂、斑块内出血（IPH）、富含脂质坏死核心（LRNC）的存在以及LRNC体积增加）之间的关系，通过磁共振成像（MRI）对AIM-HIGH中已确定血管疾病的患者进行了检查。共有214名受试者接受了颈动脉MRI检查，Core Lab对斑块负担、组织含量和MRI改良的AHA病变类型进行了图像质量可接受的评估。我们发现77%的受试者有颈动脉斑块，52%有含脂斑块，11%有晚期的AHA vi型病变，可能有表面缺陷、IPH或附壁血栓。vi型病变与年龄增长有关（OR=2.6 / 5年，p<0.001）。在调整年龄后，这些病变与脑血管病史（OR=4.1, p=0.01）、较高的脂蛋白(a)水平（OR=2.0 / 1 SD增加，p=0.02）和较大的%壁容积（%WV； OR=4.6 / 1 SD增加，p<0.001）相关，但与代谢综合征负相关（OR=0.2, p=0.02）。LRNC的存在与男性性别（OR=3.2, p=0.02）和%WV （OR=3.8 / 1 SD, p<0.001）相关，但与糖尿病（OR=0.4, p=0.02）和HDL-C水平（OR=0.7 / 1 SD, p=0.02）负相关。升高的%LRNC与%WV相关（回归系数=0.36,p<0.001），与ApoA1水平负相关（回归系数= - 0.20,p=0.03）。综上所述，年龄较大、男性、脑血管病史、斑块负担较大、Lp(a)较高、HDL-C或ApoA1较低与高危斑块特征有统计学意义。代谢综合征和糖尿病在这一人群中呈负相关。
Association between clinical factors and high-risk plaque features such as thin or ruptured cap, intra-plaque hemorrhage (IPH), presence of Lipid Rich Necrotic Core (LRNC) and increased LRNC volume as assessed by Magnetic Resonance Imaging (MRI) was examined in patients with established vascular disease in AIM-HIGH. A total of 214 subjects underwent carotid MRI and had acceptable image quality for assessment of plaque burden, tissue contents and MRI-modified AHA lesion type by a Core Lab. We found that 77% of subjects had carotid plaques, 52% had lipid-containing plaques, and 11% had advanced, AHA type-VI lesions with possible surface defect, IPH or mural thrombus. Type-VI lesions were associated with older age (OR=2.6 per 5 years increase, p<0.001). After adjusting for age, these lesions were associated with history of cerebrovascular disease (OR=4.1, p=0.01), higher levels of Lipoprotein(a) (OR=2.0 per 1 SD increase, p=0.02) and larger %wall volume (%WV; OR=4.6 per 1 SD increase, p<0.001), but, were negatively associated with metabolic syndrome (OR=0.2, p=0.02). Presence of LRNC was associated with male gender (OR=3.2, p=0.02) and %WV (OR=3.8 per 1 SD, p<0.001), but, was negatively associated with diabetes (OR=0.4, p=0.02) and HDL-C levels (OR=0.7 per 1 SD, p=0.02). Increased %LRNC was associated with %WV (regression coefficient=0.36, p<0.001) and negatively associated with ApoA1 levels (regression coefficient=−0.20, p=0.03). In conclusions, older age, male gender, history of cerebrovascular disease, larger plaque burden, higher Lp(a), and lower HDL-C or ApoA1 have statistically significant associations with high-risk plaque features. Metabolic syndrome and diabetes showed negative associations in this population.
登录
查看更多内容
影响因子：
4.8
作者：
Brown, B. Gregory;Boden, William E.;Probstfield, Jeffrey R.;McBride, Ruth;Anderson, Todd;Chaitman, Bernard;Marcovina, Santica;Weintraub, William;Zhao, Xue-Qiao;Teo, Koon;Kaiser, Judith;Desvignes-Nickens, Patrice;Fleg, Jerome L.;McGovern, Mark E.;Stolzenbach, James C.;Padley, Robert J.
通讯作者：
Padley, Robert J.
影响因子：
8.3
作者：
Takaya, N;Yuan, C;Hatsukami, TS
通讯作者：
Hatsukami, TS
DOI：
10.1161/01.atv.19.11.2756
发表时间：
1999-11-01
影响因子：
8.7
作者：
Shinnar, M;Fallon, JT;Fuster, V
通讯作者：
Fuster, V
影响因子：
19.7
作者：
Singh, Navneet;Moody, Alan R.;Maggisano, Robert
通讯作者：
Maggisano, Robert
影响因子：
3.5
作者：
Dong, L.;Underhill, H. R.;Yuan, C.
通讯作者：
Yuan, C.