Which is the Best Protocol of Ovarian Stimulation Prior to Artificial Insemination by Donor
Which is the Best Protocol of Ovarian Stimulation Prior to Artificial Insemination by Donor
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供体人工授精前卵巢刺激的最佳方案是什么
DOI：
10.7669/j.issn.1001-7844.2014.01.0041
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发表时间：
2014-03
期刊：
影响因子：
--
通讯作者：
Ai-jun ZHANG
中科院分区：
文献类型：
--
作者：
Bu-fang XU;Guang-yan WANG;Wei-min FAN;Qian CHEN;Ai-jun ZHANG
目的比较克罗米芬（CC）、来曲唑、人绝经期促性腺激素（hMG）单独或联合CC或来曲唑的促排卵方案在供精人工授精（AID）中的效果。方法在这项前瞻性临床试验中，将671对准备接受AID周期的夫妇根据首次自然周期接受不同方案随机分为6组（A组，n=114），CC B组（n=101），CC + hMG组（n=124），来曲唑组（n=97），来曲唑+hMG组（n=123），hMG组（n=112）。比较6组hMG总剂量、hMG治疗时间、优势卵泡数、子宫内膜厚度、临床妊娠率、流产率、卵巢过度刺激综合征（OHSS）发生率、多胎妊娠率和取消妊娠率。结果C组和E组的hMG总用量和用药时间均显著低于F组。A组优势卵泡数明显少于其他各组，C组优势卵泡数明显多于其他各组。子宫内膜厚度B组明显低于其他各组。刺激组之间的临床妊娠率、多胎妊娠率、流产率、OHSS率和取消率无统计学差异。结论CC和来曲唑联合应用的AID周期可能需要更短的疗程和更低的促性腺激素总剂量，而临床结局相似。
Objective To compare the different ovarian stimulation protocols, clomiphene citrate (CC), letrozole, human menopausal gonadotropin (hMG) only or combined with CC or letrozole in women undergoing artificial insemination by donor (AID). Methods In this prospective clinical trial, 671 couples prepared for AID cycles were randomly allocated to 6 groups according to receive different protocols for the first time, natural cycle (group A, n=114), CC (group B, n=101), CC and hMG (group C, n=124), letrozole (group D, n=97), letrozole and hMG (group E, n=123) and hMG only (group F, n=112). Outcomes including total dose of hMG, duration of hMG therapy, dominant follicles number, endometrial thickness, rates of clinical pregnancy, miscarriage, ovarian hyperstimulation syndrome (OHSS), multiple pregnancy and cancelation were compared among the 6 groups. Results The total doses and duration of administered hMG were significantly lower in group C and group E than in group F. Dominant follicle number was significantly less in group A and more in group C than in other groups. Endometrial thickness of group B was significantly lower than that of other groups. Clinical pregnancy rate, multiple pregnancy rate, miscarriage rate, OHSS rate and cancelation rate were not statistically different among the stimulation groups. Conclusion AID cycles in which both CC and letrozole had been administered may require shorter duration and a lower total gonadotropin dose, while the clinical outcomes were similar.
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影响因子：
6.1
作者：
Mitwally, MFM;Casper, RF
通讯作者：
Casper, RF
DOI：
--
发表时间：
2004-10
期刊：
JPMA. The Journal of the Pakistan Medical Association
影响因子：
--
作者：
Mahani Im;M. Afnan
通讯作者：
Mahani Im;M. Afnan
影响因子：
6.7
作者：
Jee, Byung Chul;Ku, Seung Yup;Kim, Seok Hyun
通讯作者：
Kim, Seok Hyun
DOI：
10.1002/14651858.cd001838.pub2
发表时间：
2006
期刊：
The Cochrane database of systematic reviews
影响因子：
--
作者：
S. M. Veltman-Verhulst;B. Cohlen;E. Hughes;M. Heineman;Jane Farquhar;Anne Marjoribanks;Lethaby statistician;Andy
通讯作者：
S. M. Veltman-Verhulst;B. Cohlen;E. Hughes;M. Heineman;Jane Farquhar;Anne Marjoribanks;Lethaby statistician;Andy
影响因子：
1.3
作者：
Badawy, A.;Elnashar, A.;Totongy, M.
通讯作者：
Totongy, M.