PTPRO predicts patient prognosis and correlates with immune infiltrates in human clear cell renal cell carcinoma.
PTPRO predicts patient prognosis and correlates with immune infiltrates in human clear cell renal cell carcinoma.
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PTPRO 预测患者预后并与人透明细胞肾细胞癌的免疫浸润相关
DOI：
10.21037/tcr-19-2808
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发表时间：
2020-08
影响因子：
0.9
通讯作者：
Zhang H
中科院分区：
文献类型：
--
作者：
Gan J;Zhang H
背景蛋白酪氨酸磷酸酶受体O型（PTPRO）在多种人类癌症中的肿瘤抑制作用已被描述;然而，PTPRO在人类透明细胞肾细胞癌（ccRCC）中的临床意义仍不清楚。方法应用Oncomine数据库、GEO数据集和TCGA数据集，分析PTPRO在肾细胞癌（RCC）中的表达。采用Kaplan-Meier曲线和考克斯比例风险模型分析PTPRO与ccRCC总生存期的关系。通过基因本体论（GO）分析和基因集富集分析（GSEA）探讨PTPRO可能参与的信号通路。通过肿瘤免疫评估资源（TIMER）数据库研究了ccRCC中PTPRO与免疫浸润之间的相关性。使用癌细胞系百科全书（CCLE）数据集、GEO数据集和cBioPortal数据库分析RCC中PTPRO mRNA表达与其甲基化之间的关联。通过MethSurv数据库估计PTPRO甲基化对总生存期的影响。结果PTPRO在肾癌组织中的表达明显降低。此外，PTPRO的低表达与ccRCC的总生存率较差相关，特别是在晚期患者中。多因素考克斯回归分析显示PTPRO表达是ccRCC总生存期的独立预后预测因子。值得注意的是，发现PTPRO与免疫信号传导和免疫细胞浸润的激活相关。此外，在ccRCC中观察到PTPRO甲基化，并且PTPRO甲基化预测ccRCC的不良预后。结论PTPRO在RNA和DNA甲基化水平上均具有作为预测预后的生物标志物的潜力，且PTPRO表达与ccRCC患者的免疫浸润密切相关。
Background The tumor-suppressive role of protein tyrosine phosphatase receptor type O (PTPRO) has been described in a variety of human cancers; however, the clinical significance of PTPRO in human clear cell renal cell carcinoma (ccRCC) remains unclear. Methods PTPRO expression in renal cell carcinoma (RCC) was analyzed via the Oncomine database, Gene Expression Omnibus (GEO) datasets, and The Cancer Genome Atlas (TCGA) datasets. The Kaplan-Meier curves and Cox proportional hazards model were used to evaluate the relationship of PTPRO with overall survival in ccRCC. Gene ontology (GO) analysis and gene set enrichment analysis (GSEA) were performed to explore the signaling pathways in which PTPRO may be involved. The correlation between PTPRO and immune infiltrates in ccRCC was investigated via Tumor Immune Estimation Resource (TIMER) database. The association between PTPRO mRNA expression and its methylation in RCC was analyzed using the Cancer Cell Line Encyclopedia (CCLE) dataset, GEO dataset, and cBioPortal database. The impact of PTPRO methylation on overall survival was estimated by the MethSurv database. Results We showed that the expression of PTPRO was significantly lower in human RCC. Moreover, the lower expression of PTPRO was associated with worse overall survival in ccRCC, particularly in the advanced stage patients. Multivariate Cox regression analysis revealed the expression of PTPRO as an independent prognostic predictor for overall survival of ccRCC. Of note, PTPRO was found to be associated with the activation of immune signaling and immune cell infiltration. Furthermore, methylation of PTPRO was prevalently observed in ccRCC, and methylation of PTPRO predicted the poor outcome of ccRCC. Conclusions Our findings suggested that PTPRO at both RNA and DNA methylation levels had the potential as a prognostic biomarker for predicting prognosis, and PTPRO expression was closely associated with immune infiltration in ccRCC patients.
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影响因子：
7.3
作者：
Gao J;Aksoy BA;Dogrusoz U;Dresdner G;Gross B;Sumer SO;Sun Y;Jacobsen A;Sinha R;Larsson E;Cerami E;Sander C;Schultz N
通讯作者：
Schultz N
PTPRO 启动子甲基化预示着 HER2 阳性乳腺癌的较差预后：个性化治疗的指征
影响因子：
7.4
作者：
Huang YT;Li FF;Ke C;Li Z;Li ZT;Zou XF;Zheng XX;Chen YP;Zhang H
通讯作者：
Zhang H
PTPRO 通过 ERBB2 的去磷酸化和内体内化来抑制 ERBB2 驱动的乳腺肿瘤发生
影响因子：
8
作者：
Dong H;Ma L;Gan J;Lin W;Chen C;Yao Z;Du L;Zheng L;Ke C;Huang X;Song H;Kumar R;Yeung SC;Zhang H
通讯作者：
Zhang H
影响因子：
254.7
作者：
Siegel, Rebecca;Ma, Jiemin;Jemal, Ahmedin
通讯作者：
Jemal, Ahmedin
影响因子：
64.8
作者：
Ghandi, Mahmoud;Huang, Franklin W.;Sellers, William R.
通讯作者：
Sellers, William R.