Quercetin as an Agent for Protecting the Bone: A Review of the Current Evidence.
Quercetin as an Agent for Protecting the Bone: A Review of the Current Evidence.
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DOI：
10.3390/ijms21176448
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发表时间：
2020-09-03
影响因子：
5.6
通讯作者：
Ima-Nirwana S
中科院分区：
文献类型：
--
作者：
Wong SK;Chin KY;Ima-Nirwana S
槲皮素是一种富含于水果和蔬菜中的类黄酮。它具有广泛的生物活性，从而表明在预防疾病和促进健康方面的作用。本文就槲皮素的骨保护作用及其作用机制作一综述。动物研究发现，槲皮素对骨骼的作用在很大程度上是保护性的，少数研究报告了负面结果。槲皮素显示抑制RANKL介导的破骨细胞生成、成骨细胞凋亡、氧化应激和炎症反应，同时促进骨生成、血管生成、抗氧化剂表达、脂肪细胞凋亡和破骨细胞凋亡。可能的潜在机制涉及Wnt、NF-κB、Nrf 2、SMAD依赖性以及内源性和外源性凋亡途径的调节。另一方面，槲皮素显示对MAPK信号通路发挥复杂和竞争性作用，以协调骨代谢，导致对骨的刺激和抑制作用并行。总体相互作用被认为对骨产生积极影响。考虑到槲皮素在调节骨稳态中的重要贡献，它可以被认为是一种经济且有前途的改善骨健康的药物。记录的临床前发现有待于人体临床试验的进一步验证。
Quercetin is a flavonoid abundantly found in fruits and vegetables. It possesses a wide spectrum of biological activities, thus suggesting a role in disease prevention and health promotion. The present review aimed to uncover the bone-sparing effects of quercetin and its mechanism of action. Animal studies have found that the action of quercetin on bone is largely protective, with a small number of studies reporting negative outcomes. Quercetin was shown to inhibit RANKL-mediated osteoclastogenesis, osteoblast apoptosis, oxidative stress and inflammatory response while promoting osteogenesis, angiogenesis, antioxidant expression, adipocyte apoptosis and osteoclast apoptosis. The possible underlying mechanisms involved are regulation of Wnt, NF-κB, Nrf2, SMAD-dependent, and intrinsic and extrinsic apoptotic pathways. On the other hand, quercetin was shown to exert complex and competing actions on the MAPK signalling pathway to orchestrate bone metabolism, resulting in both stimulatory and inhibitory effects on bone in parallel. The overall interaction is believed to result in a positive effect on bone. Considering the important contributions of quercetin in regulating bone homeostasis, it may be considered an economical and promising agent for improving bone health. The documented preclinical findings await further validation from human clinical trials.
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影响因子：
5.6
作者：
Chiu YH;Ritchlin CT
通讯作者：
Ritchlin CT
DOI：
10.1002/jor.23845
发表时间：
2018-06
期刊：
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
影响因子：
--
作者：
Ball AN;Donahue SW;Wojda SJ;McIlwraith CW;Kawcak CE;Ehrhart N;Goodrich LR
通讯作者：
Goodrich LR
影响因子：
3.6
作者：
Egert, Sarah;Bosy-Westphal, Anja;Mueller, Manfred J.
通讯作者：
Mueller, Manfred J.
影响因子：
5.6
作者：
Casado-Diaz, Antonio;Anter, Jaouad;Manuel Quesada-Gomez, Jose
通讯作者：
Manuel Quesada-Gomez, Jose
影响因子：
6.2
作者：
Briot K;Roux C
通讯作者：
Roux C