Insights into human cerebral white matter maturation and degeneration across the adult lifespan.
Insights into human cerebral white matter maturation and degeneration across the adult lifespan.
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DOI：
10.1016/j.neuroimage.2021.118727
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发表时间：
2022-02-15
期刊：
影响因子：
5.7
通讯作者：
Bouhrara M
中科院分区：
文献类型：
--
作者：
Kiely M;Triebswetter C;Cortina LE;Gong Z;Alsameen MH;Spencer RG;Bouhrara M
白色物质（WM）的微观结构特性在整个成人寿命和神经元疾病中发生变化。了解由于衰老引起的微结构变化对于将其与神经病理学变化区分开来至关重要。我们的研究对147名年龄范围从21岁到94岁的认知功能正常的受试者进行了一个大的队列研究，评估了WM微观结构中与性别和年龄相关的差异。具体来说，我们使用扩散张量成像（DTI）磁共振成像（MRI）指数，髓鞘和轴突密度的敏感措施，髓鞘水分数（MWF），髓鞘片内捕获的水的信号的分数的措施，以探测这些差异。此外，我们研究了MWF和DTI指数之间的区域相关性，以评估这些指标是否提供了MWF的补充信息。虽然两性异形，总体而言，不显着的，我们观察到区域依赖性差异MWF，即髓鞘含量，轴突密度与年龄，并发现两者表现出非线性的，但不同的，与年龄的关联。此外，DTI指数与MWF中度相关，表明它们对髓鞘含量以及WM组织的其他成分（如轴突密度）具有良好的敏感性。我们的MRI指标所捕获的微结构差异，沿着其与MWF的弱关联，强烈表明在多参数方法中结合这些结果测量的潜在价值。此外，我们的研究结果支持后入先出和增益预测损失的WM成熟和退化的假设。事实上，我们的研究结果表明，后部WM区域免于神经变性相比，前部区域，而WM髓鞘形成遵循时间对称的时间过程中的成年人的寿命。
White matter (WM) microstructural properties change across the adult lifespan and with neuronal diseases. Understanding microstructural changes due to aging is paramount to distinguish them from neuropathological changes. Conducted on a large cohort of 147 cognitively unimpaired subjects, spanning a wide age range of 21 to 94 years, our study evaluated sex- and age-related differences in WM microstructure. Specifically, we used diffusion tensor imaging (DTI) magnetic resonance imaging (MRI) indices, sensitive measures of myelin and axonal density, and myelin water fraction (MWF), a measure of the fraction of the signal of the water trapped within the myelin sheets, to probe these differences. Furthermore, we examined regional correlations between MWF and DTI indices to evaluate whether these metrics provide information complementary to MWF. While sexual dimorphism was, overall, nonsignificant, we observed region-dependent differences in MWF, that is, myelin content, and axonal density with age and found that both exhibit nonlinear, but distinct, associations with age. Furthermore, DTI indices were moderately correlated with MWF, indicating their good sensitivity to myelin content as well as to other constituents of WM tissue such as axonal density. The microstructural differences captured by our MRI metrics, along with their weak associations with MWF, strongly indicate the potential value of combining these outcome measures in a multiparametric approach. Furthermore, our results support the last-in-first-out and the gain-predicts-loss hypotheses of WM maturation and degeneration. Indeed, our results indicate that the posterior WM regions are spared from neurodegeneration as compared to anterior regions, while WM myelination follows a temporally symmetric time course across the adult life span.
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DOI：
10.1111/jon.12537
发表时间：
2018-11
期刊：
Journal of neuroimaging : official journal of the American Society of Neuroimaging
影响因子：
--
作者：
Bouhrara M;Reiter DA;Maring MC;Bonny JM;Spencer RG
通讯作者：
Spencer RG
影响因子：
5.7
作者：
Arshad M;Stanley JA;Raz N
通讯作者：
Raz N
影响因子：
3.3
作者：
Guo, Junyu;Ji, Qing;Reddick, Wilburn E.
通讯作者：
Reddick, Wilburn E.
影响因子：
3.2
作者：
Arfanakis, Konstantinos;Gui, Minzhi;Carew, John D.
通讯作者：
Carew, John D.
影响因子：
4.2
作者：
Bouhrara, Mustapha;Rejimon, Abinand C.;Spencer, Richard G.
通讯作者：
Spencer, Richard G.