Functional and structural modifications of influenza antibodies during pregnancy.
Functional and structural modifications of influenza antibodies during pregnancy.
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DOI：
10.1016/j.isci.2022.104088
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发表时间：
2022-04-15
期刊：
影响因子：
5.8
通讯作者：
Pasetti MF
中科院分区：
文献类型：
--
作者：
Jennewein MF;Kosikova M;Noelette FJ;Radvak P;Boudreau CM;Campbell JD;Chen WH;Xie H;Alter G;Pasetti MF
怀孕代表了一种独特的耐受性免疫状态，可能会改变感染和疫苗反应的敏感性，我们表征了季节性影响季节性影响孕妇和非孕妇的疫苗菌株。观察到孕妇减少了血凝素亚型-1（H1）-IgG，IgG1，IgG2和IgG3，血凝性抑制作用，第1组和2个茎IgG滴度。功能（即单核细胞吞噬作用和补体沉积）在妊娠中降低了。 （怀孕与非孕育）由H1FcγR1结合，H1-IGG水平以及FAB和FC糖基化隔离。有效的位置运输
妊娠导致影响力抗体的结构和功能调节。
抗体具有差异的结合能力，FC/FAB糖基化和功能。
抗体聚糖针对低炎症和有效的斑点转移。
免疫标志物的多元分析隔离了孕妇和非孕妇。
病毒学；
Pregnancy represents a unique tolerogenic immune state which may alter susceptibility to infection and vaccine response. Here, we characterized humoral immunity to seasonal influenza vaccine strains in pregnant and non-pregnant women. Although serological responses to influenza remained largely intact during late pregnancy, distinct modifications were observed. Pregnant women had reduced hemagglutinin subtype-1 (H1)- IgG, IgG1, IgG2, and IgG3, hemagglutination inhibition, and group 1 and 2 stem IgG titers. Intriguingly, H1-specific avidity and FcγR1 binding increased, and influenza antibodies had distinct Fc and Fab glycans characterized by increased di-galactosylation and di-sialylation. H1-specific Fc-functionality (i.e. monocyte phagocytosis and complement deposition) was moderately reduced in pregnancy. Multivariate antibody analysis revealed two distinct populations (pregnant vs. non-pregnant) segregated by H1 FcγR1 binding, H1-IgG levels, and Fab and Fc glycosylation. Our results demonstrated a structural and functional modulation of influenza humoral immunity during pregnancy that was antigen-specific and consistent with reduced inflammation and efficient placental transport Pregnancy resulted in structural and functional modulation of influenza antibodies. Antibodies had differential binding capacity, Fc/Fab glycosylation, and function. Antibody glycans directed toward low inflammation and efficient placental transfer. Multivariate analysis of immune markers segregated pregnant and non-pregnant women. Virology; Pregnancy
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DOI：
10.1093/cid/ciw559
发表时间：
2016-12-01
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Amirthalingam G;Campbell H;Ribeiro S;Fry NK;Ramsay M;Miller E;Andrews N
通讯作者：
Andrews N
影响因子：
3.6
作者：
Blanchard-Rohner, Geraldine;Meier, Sara;Siegrist, Claire-Anne
通讯作者：
Siegrist, Claire-Anne
DOI：
10.1074/mcp.m114.039537
发表时间：
2014-11
期刊：
Molecular & cellular proteomics : MCP
影响因子：
--
作者：
Bondt A;Rombouts Y;Selman MH;Hensbergen PJ;Reiding KR;Hazes JM;Dolhain RJ;Wuhrer M
通讯作者：
Wuhrer M
影响因子：
7.8
作者：
Alter G;Ottenhoff THM;Joosten SA
通讯作者：
Joosten SA
影响因子：
7.2
作者：
通讯作者：
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