Thalamic white matter macrostructure and subnuclei volumes in Parkinson's disease depression.
Thalamic white matter macrostructure and subnuclei volumes in Parkinson's disease depression.
复制标题
DOI：
10.1038/s41531-021-00270-y
复制
发表时间：
2022-01-10
期刊：
影响因子：
--
通讯作者：
Weil RS
中科院分区：
文献类型：
--
作者：
Bhome R;Zarkali A;Thomas GEC;Iglesias JE;Cole JH;Weil RS
抑郁是帕金森病（PD）常见的非运动特征，发病率高，治疗难度大，丘脑是基底节-丘脑皮质网络的重要组成部分，在PD和抑郁的发病机制中起着关键作用，但参与PD抑郁的丘脑亚核的确切位置尚未确定。我们对76名PD患者进行了结构和弥散加权成像（DWI），以评估PD抑郁与丘脑核下灰质和白色物质变化之间的关系。我们使用丘脑分割方法将丘脑分为50个组成亚核（每个半球25个）。固定为基础的分析被用来计算平均纤维横截面（FC）的白色物质束连接到每个亚核。我们评估了基线和14-20个月随访时的容量和FC。一个广义线性混合模型被用来评估抑郁症，亚核体积和平均FC每个丘脑亚核之间的关系。我们发现PD患者的抑郁评分与右下枕前（普阿）亚核体积相关。抗抑郁药的使用与较高的右侧普阿体积相关，表明治疗可能具有保护作用。随访后，抑郁评分与几乎所有与丘脑亚核相连的脑束的白色脑束宏观结构减少相关。总之，我们的工作暗示了右侧普阿作为PD抑郁症的相关神经结构，未来的工作应该评估其作为PD抑郁症治疗靶点的潜力。
Depression is a common non-motor feature of Parkinson’s disease (PD) which confers significant morbidity and is challenging to treat. The thalamus is a key component in the basal ganglia-thalamocortical network critical to the pathogenesis of PD and depression but the precise thalamic subnuclei involved in PD depression have not been identified. We performed structural and diffusion-weighted imaging (DWI) on 76 participants with PD to evaluate the relationship between PD depression and grey and white matter thalamic subnuclear changes. We used a thalamic segmentation method to divide the thalamus into its 50 constituent subnuclei (25 each hemisphere). Fixel-based analysis was used to calculate mean fibre cross-section (FC) for white matter tracts connected to each subnucleus. We assessed volume and FC at baseline and 14–20 months follow-up. A generalised linear mixed model was used to evaluate the relationship between depression, subnuclei volume and mean FC for each thalamic subnucleus. We found that depression scores in PD were associated with lower right pulvinar anterior (PuA) subnucleus volume. Antidepressant use was associated with higher right PuA volume suggesting a possible protective effect of treatment. After follow-up, depression scores were associated with reduced white matter tract macrostructure across almost all tracts connected to thalamic subnuclei. In conclusion, our work implicates the right PuA as a relevant neural structure in PD depression and future work should evaluate its potential as a therapeutic target for PD depression.
登录
查看更多内容
影响因子：
4.1
作者：
DeLong, Mahlon;Wichmann, Thomas
通讯作者：
Wichmann, Thomas
影响因子：
16.6
作者：
Honjoh S;Sasai S;Schiereck SS;Nagai H;Tononi G;Cirelli C
通讯作者：
Cirelli C
影响因子：
5.7
作者：
Cardoso, Ellison Fernando;Maia, Fernanda Martins;Amaro, Edson, Jr.
通讯作者：
Amaro, Edson, Jr.
影响因子：
4.1
作者：
Halliday, Glenda M.
通讯作者：
Halliday, Glenda M.
影响因子：
4.1
作者：
Jacob EL;Gatto NM;Thompson A;Bordelon Y;Ritz B
通讯作者：
Ritz B