Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus.
Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus.
复制标题
维生素 C 可改善非胰岛素依赖性糖尿病患者的内皮依赖性血管舒张。
DOI：
10.1172/jci118394
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Creager,MA
中科院分区：
文献类型：
--
作者：
Ting,HH;Timimi,FK;Boles,KS;Creager,SJ;Ganz,P;Creager,MA
Endothelium-dependent vasodilation is impaired in humans with diabetes mellitus. Inactivation of endothelium-derived nitric oxide by oxygen-derived free radicals contributes to abnormal vascular reactivity in experimental models of diabetes. To determine whether this observation is relevant to humans, we tested the hypothesis that the antioxidant, vitamin C, could improve endothelium-dependent vasodilation in forearm resistance vessels of patients with non-insulin-dependent diabetes mellitus. We studied 10 diabetic subjects and 10 age-matched, nondiabetic control subjects. Forearm blood flow was determined by venous occlusion plethysmography. Endothelium-dependent vasodilation was assessed by intraarterial infusion of methacholine (0.3-10 micrograms/min). Endothelium-independent vasodilation was measured by intraarterial infusion of nitroprusside (0.3-10 micrograms/min) and verapamil (10-300 micrograms/min). Forearm blood flow dose-response curves were determined for each drug before and during concomitant intraarterial administration of vitamin C (24 mg/min). In diabetic subjects, endothelium-dependent vasodilation to methacholine was augmented by simultaneous infusion of vitamin C (P = 0.002); in contrast, endothelium-independent vasodilation to nitroprusside and to verapamil were not affected by concomitant infusion of vitamin C (P = 0.9 and P = 0.4, respectively). In nondiabetic subjects, vitamin C administration did not alter endothelium-dependent vasodilation (P = 0.8). We conclude that endothelial dysfunction in forearm resistance vessels of patients with non-insulin-dependent diabetes mellitus can be improved by administration of the antioxidant, vitamin C. These findings support the hypothesis that nitric oxide inactivation by oxygen-derived free radicals contributes to abnormal vascular reactivity in diabetes.
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研究抗氧化剂抗坏血酸、半胱氨酸和氨苯砜对吞噬细胞介导的人 α-1-蛋白酶抑制剂的体外氧化失活的保护作用。
DOI：
10.1164/arrd.1985.132.5.1049
发表时间：
1985
期刊：
The American review of respiratory disease
影响因子：
--
作者：
A. Theron;R. Anderson
通讯作者：
R. Anderson
异常血管反应中花生四烯酸代谢产生的氧自由基。
DOI：
10.1164/ajrccm/136.2.474
发表时间：
1987
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Kontos,HA
通讯作者：
Kontos,HA
影响因子：
64.8
作者：
KUGIYAMA, K;KERNS, SA;HENRY, PD
通讯作者：
HENRY, PD
DOI：
10.1152/ajpheart.1989.257.5.h1327
发表时间：
1989-11
期刊：
The American journal of physiology
影响因子：
--
作者：
B. Tesfamariam;J. Jakubowski;Richard A. Cohen
通讯作者：
B. Tesfamariam;J. Jakubowski;Richard A. Cohen
影响因子：
15.9
作者：
KAWAMURA, M;HEINECKE, JW;CHAIT, A
通讯作者：
CHAIT, A