E-cadherin expression in primary carcinomas of the breast and its distant metastases.
E-cadherin expression in primary carcinomas of the breast and its distant metastases.
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DOI：
10.1186/bcr651
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Kleer CG
中科院分区：
文献类型：
--
作者：
Kowalski PJ;Rubin MA;Kleer CG
E-钙粘蛋白的异常表达与乳腺癌患者转移的发生有关。尽管E-钙粘蛋白在原发性乳腺肿瘤中的表达已被研究，但对其在远处转移部位的表达知之甚少。我们研究了原发性乳腺癌中 E-钙粘蛋白的表达与其远处、非淋巴结转移之间的关系。对 30 名原发性浸润性乳腺癌及其远处转移患者的组织进行了 E-钙粘蛋白的免疫组织化学分析。 E-钙粘蛋白表达被评估为正常或异常（与正常内部阳性对照相比降低或不存在）。 22 例 (73%) 浸润性癌为导管癌，8 例 (27%) 为小叶癌。在原发性浸润性导管癌中，55% (12/22) 的 E-cadherin 表达正常，45% (10/22) 的表达异常。所有转移瘤均以与（12个肿瘤）相同的强度或比（10个肿瘤）相应原发灶更强的强度表达E-钙粘蛋白。在浸润性小叶癌中，八个原发癌之一（12%）和所有转移瘤均在细胞膜中表达 E-钙粘蛋白，但它们在细胞质中积累了该蛋白。异常的 E-钙粘蛋白表达在进展为远处转移的浸润性导管癌中很常见。远处转移瘤始终表达 E-钙粘蛋白，通常比原发肿瘤更强。浸润性小叶癌具有不同的 E-钙粘蛋白表达模式，表明 E-钙粘蛋白在这种形式的乳腺癌中发挥不同的作用。
Aberrant expression of E-cadherin has been associated with the development of metastases in patients with breast cancer. Even though the expression of E-cadherin has been studied in primary breast tumors, little is known about its expression at the distant metastatic sites. We investigate the relationship between E-cadherin expression in primary breast carcinoma and their distant, non-nodal metastases. Immunohistochemical analysis of E-cadherin was performed in tissues from 30 patients with primary invasive breast carcinoma and their distant metastases. E-cadherin expression was evaluated as normal or aberrant (decreased when compared with normal internal positive controls, or absent). Twenty-two (73%) invasive carcinomas were ductal, and eight (27%) were lobular. Of the primary invasive ductal carcinomas, 55% (12/22) had normal E-cadherin expression and 45% (10/22) had aberrant expression. All of the metastases expressed E-cadherin with the same intensity as (12 tumors) or with stronger intensity than (10 tumors) the corresponding primaries. Of the invasive lobular carcinomas, one of eight (12%) primary carcinomas and none of the metastases expressed E-cadherin in the cell membranes, but they accumulated the protein in the cytoplasm. Aberrant E-cadherin expression is frequent in invasive ductal carcinomas that progress to develop distant metastases. Distant metastases consistently express E-cadherin, often more strongly than the primary tumor. Invasive lobular carcinomas have a different pattern of E-cadherin expression, suggesting a different role for E-cadherin in this form of breast carcinoma.
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影响因子：
11.4
作者：
Berx, G;CletonJansen, AM;vanRoy, F
通讯作者：
vanRoy, F
影响因子：
4.8
作者：
Day, ML;Zhao, X;Day, KC
通讯作者：
Day, KC
影响因子：
8.8
作者：
Dorudi, S;Hanby, A M;Poulsom, R;Northover, J;Hart, I R
通讯作者：
Hart, I R
影响因子：
7.3
作者：
RASBRIDGE, SA;GILLETT, CE;MILLIS, RR
通讯作者：
MILLIS, RR
影响因子：
6.4
作者：
Sarrió, D;Moreno-Bueno, G;Palacios, J
通讯作者：
Palacios, J