KEGG: integrating viruses and cellular organisms.
KEGG: integrating viruses and cellular organisms.
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DOI：
10.1093/nar/gkaa970
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发表时间：
2021-01-08
影响因子：
14.9
通讯作者：
Tanabe M
中科院分区：
文献类型：
--
作者：
Kanehisa M;Furumichi M;Sato Y;Ishiguro-Watanabe M;Tanabe M
KEGG（https：//www.kegg.jp/）是一个人工管理的资源，整合了18个数据库，分为系统，基因组，化学和健康信息。它还提供KEGG映射工具，使人们能够从基因组序列和其他分子数据集了解细胞和生物体水平的功能。KEGG作图是一种基于功能同源物概念的分子构建块重构分子网络系统的预测方法。自KEGG NETWORK数据库推出以来，各种疾病都与网络变体有关，这些网络变体是由人类基因变体、病毒、其他病原体和环境因素引起的扰动分子网络。网络变异图被创建为相关网络的对齐集合，例如，显示不同病毒如何抑制或激活特定的细胞信号传导途径。KEGG通路图现在与NETWORK数据库中的网络变异图以及MONORTH数据库中KEGG模块和反应模块的保守功能单元集成。功能性直向同源物的KO数据库继续得到改进，并且病毒科斯正在扩展，以更好地理解病毒-细胞相互作用并能够预测病毒扰动。
KEGG (https://www.kegg.jp/) is a manually curated resource integrating eighteen databases categorized into systems, genomic, chemical and health information. It also provides KEGG mapping tools, which enable understanding of cellular and organism-level functions from genome sequences and other molecular datasets. KEGG mapping is a predictive method of reconstructing molecular network systems from molecular building blocks based on the concept of functional orthologs. Since the introduction of the KEGG NETWORK database, various diseases have been associated with network variants, which are perturbed molecular networks caused by human gene variants, viruses, other pathogens and environmental factors. The network variation maps are created as aligned sets of related networks showing, for example, how different viruses inhibit or activate specific cellular signaling pathways. The KEGG pathway maps are now integrated with network variation maps in the NETWORK database, as well as with conserved functional units of KEGG modules and reaction modules in the MODULE database. The KO database for functional orthologs continues to be improved and virus KOs are being expanded for better understanding of virus-cell interactions and for enabling prediction of viral perturbations.
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影响因子：
14.9
作者：
Federhen S
通讯作者：
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影响因子：
14.9
作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
14.9
作者：
Kanehisa M;Sato Y;Furumichi M;Morishima K;Tanabe M
通讯作者：
Tanabe M