The double-edged sword: Neurotoxicity of chemotherapy.
The double-edged sword: Neurotoxicity of chemotherapy.
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DOI：
10.1016/j.blre.2014.09.012
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发表时间：
2015-03
期刊：
影响因子：
7.4
通讯作者：
DeAngelis LM
中科院分区：
文献类型：
--
作者：
Magge RS;DeAngelis LM
治疗恶性血液病的可用疗法的数量继续快速增长。不幸的是，这些治疗中的许多同时具有中枢和外周神经系统毒性，潜在地限制了患者耐受整个疗程的能力。化疗的神经毒性是常见的，仅次于骨髓抑制，是限制剂量的原因。本文综述了新近上市的治疗药物布妥昔单抗、维多丁和blinatumomab以及经典药物甲氨蝶呤、长春花碱和铂的神经毒性。虽然周围神经病变在许多药物中很常见，但其他并发症，如癫痫发作和脑病，可能需要更多的立即关注。迅速认识到不良的神经影响可能导致更早的治疗和适当的剂量调整方案。此外，对常见毒性的了解可能有助于区分与化疗相关的症状和癌症向中枢神经系统的实际进展。
The number of available therapies for hematologic malignancies continues to grow at a rapid pace. Unfortunately, many of these treatments carry both central and peripheral nervous system toxicity, potentially limiting a patient's ability to tolerate a full course of treatment. Neurotoxicity with chemotherapy is common and second only to myelosuppression as a reason to limit dosing. This review addresses the neurotoxicity of newly available therapeutic agents including brentuximab vedotin and blinatumomab as well as classic ones such as methotrexate, vinca alkaloids and platinums. Although peripheral neuropathy is common with many drugs, other complications such as seizures and encephalopathy may require more immediate attention. Rapid recognition of adverse neurologic effects may lead to earlier treatment and appropriate adjustment of dosing regimens. In addition, knowledge of common toxicities may help differentiate chemotherapy-related symptoms from actual progression of cancer into the CNS.
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