Bisphosphonates in dentistry: Historical perspectives, adverse effects, and novel applications.
Bisphosphonates in dentistry: Historical perspectives, adverse effects, and novel applications.
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牙科中的双膦酸盐：历史观点、不良反应和新应用。
DOI：
10.1016/j.bone.2021.115933
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发表时间：
2021-06
期刊：
影响因子：
4.1
通讯作者：
Ebetino FH
中科院分区：
文献类型：
--
作者：
Sedghizadeh PP;Sun S;Jones AC;Sodagar E;Cherian P;Chen C;Junka AF;Neighbors JD;McKenna CE;Russell RGG;Ebetino FH
关于双膦酸盐在牙科中的潜在作用的研究可以追溯到20世纪60年代的物理化学研究，而双膦酸盐药理学的发现部分可以与其中的一些工作联系起来。从那时起，关于双膦酸盐对骨代谢影响的平行研究继续进行，而牙科领域的努力包括双膦酸盐对牙石，龋齿和牙槽骨丢失的影响的研究。虽然这类药物在牙科领域的一些效用已被确定，导致其在各种牙科制剂和一些牙科临床应用中的实验性使用，但双膦酸盐在颌骨中的不良反应也受到了关注。最近，正在研究某些双膦酸盐，特别是那些具有强骨靶向特性但生化作用有限的双膦酸盐（低效价双膦酸盐），作为与该药物类别的其他更强效成员相关的不良反应的局部治疗。此外，正在研究低效力的双膦酸盐类似物作为载体，将活性药物靶向到颌骨的矿物表面。这些后者的努力已经被设计用于预防和治疗口腔问题，例如与口腔手术和植入物相关的感染。对双膦酸盐类的效用和机理理解的进展可能会为牙齿健康的多个方面的管理提供额外的口腔治疗选择。
Studies of the potential role of bisphosphonates in dentistry date back to physical chemical research in the 1960s, and the genesis of the discovery of bisphosphonate pharmacology in part can be linked to some of this work. Since that time, parallel research on the effects of bisphosphonates on bone metabolism continued, while efforts in the dental field included studies of bisphosphonate effects on dental calculus, caries, and alveolar bone loss. While some utility of this drug class in the dental field was identified, leading to their experimental use in various dentrifice formulations and in some dental applications clinically, adverse effects of bisphosphonates in the jaws have also received attention. Most recently, certain bisphosphonates, particularly those with strong bone targeting properties, but limited biochemical effects (low potency bisphosphonates), are being studied as a local remedy for the concerns of adverse effects associated with other more potent members of this drug class. Additionally, low potency bisphosphonate analogs are under study as vectors to target active drugs to the mineral surfaces of the jawbones. These latter efforts have been devised for the prevention and treatment of oral problems, such as infections associated with oral surgery and implants. Advances in the utility and mechanistic understanding of the bisphosphonate class may enable additional oral therapeutic options for the management of multiple aspects of dental health.
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DOI：
10.1016/j.joms.2014.07.004
发表时间：
2014-12
期刊：
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
影响因子：
--
作者：
Cheong S;Sun S;Kang B;Bezouglaia O;Elashoff D;McKenna CE;Aghaloo TL;Tetradis S
通讯作者：
Tetradis S
影响因子：
4.3
作者：
BRUNSVOLD, MA;CHAVES, ES;WOOD, R
通讯作者：
WOOD, R
影响因子：
4.9
作者：
Dios, P. Diz;Carmona, I. Tomas;Fernandez, M. Alvarez
通讯作者：
Fernandez, M. Alvarez
影响因子：
64.8
作者：
FLEISCH, H;RUSSEL, RGG;STRAUMANN, F
通讯作者：
STRAUMANN, F
影响因子：
5
作者：
Ballal, N. V.;Das, S.;Mohn, D.
通讯作者：
Mohn, D.