Melatonin in the afternoons of a gradually advancing sleep schedule enhances the circadian rhythm phase advance.
Melatonin in the afternoons of a gradually advancing sleep schedule enhances the circadian rhythm phase advance.
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DOI：
10.1007/s00213-012-2869-8
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发表时间：
2013-02
影响因子：
3.4
通讯作者：
Eastman, Charmane I.
中科院分区：
文献类型：
--
作者：
Crowley, Stephanie J.;Eastman, Charmane I.
关键词：
我们测试了一些方法来提前(提前)昼夜节律，而不会在节律和睡眠之间产生错位。我们之前测试了1)逐渐提前的睡眠/黑暗时间表加上早上的强光和下午/晚上的褪黑素；以及2)只有早上的强光的相同的睡眠时间表。现在我们报道相同的睡眠时间表，只有下午/晚上的褪黑素。与安慰剂相比，检查褪黑素对阶段推进、嗜睡和表现的反应。12名成年人(5名女性)，年龄20-45岁(平均±SD=28.3±7.3岁)，完成了这项受试者内的安慰剂对照平衡研究。参与者在9个基准日内按固定的8小时睡眠时间表睡觉。然后，将睡眠/黑暗时间提前1小时/天，连续治疗3天。参与者在第一个治疗日的基线睡眠中点(产生阶段进展的最佳时间)前11小时服用3毫克褪黑素或安慰剂，并在随后的每一天提前1小时服用。测定治疗前后的暗光褪黑素发作(DLMO)值。参与者在整个研究过程中对主观症状进行了评分。他们完成了精神运动警戒任务(PVT)，并对每天从服药前1小时到就寝时间的困倦程度进行了评级。与安慰剂(0.7±0.7小时)相比，褪黑素显著提前(1.3±0.7小时)；然而，在摄入褪黑素和上床前的几个小时内，褪黑素会导致嗜睡和表现减退。在逐渐提前的睡眠计划中添加下午/晚上的褪黑素会增加睡眠的相位提前，但考虑到副作用，如困倦，最好使用早上明亮的光线，或许还可以使用较低剂量的褪黑素。
We test methods to advance (shift earlier) circadian rhythms without producing misalignment between rhythms and sleep. We previously tested 1) a gradually advancing sleep/dark schedule plus morning bright light and afternoon/evening melatonin; and 2) the same sleep schedule with only morning bright light. Now we report on the same sleep schedule with only afternoon/evening melatonin. To examine phase advances, sleepiness and performance in response to melatonin compared to placebo. Twelve adults (5 female) aged 20–45 years (mean ± SD = 28.3 ± 7.3 years) completed this within-subjects placebo-controlled counterbalanced study. Participants slept on fixed 8-hour sleep schedules for 9 baseline days. Then, sleep/dark was advanced by 1 h/day for 3 consecutive days of treatment. Participants took 3 mg of melatonin or placebo 11 hours before baseline sleep midpoint (the optimal time to produce phase advances) on the first treatment day and 1 hour earlier each subsequent day. We measured the dim light melatonin onset (DLMO) before and after treatment. Participants rated subjective symptoms throughout the study. They completed the Psychomotor Vigilance Task (PVT) and rated sleepiness from 1 h before pill ingestion until bedtime each treatment day. Melatonin produced significantly larger advances (1.3 ± 0.7 h) compared to placebo (0.7 ± 0.7 h); however, in the hours between melatonin ingestion and bed, melatonin caused sleepiness and performance decrements. Adding afternoon/evening melatonin to the gradually advancing sleep schedule increased the phase advance, but given the side effects, like sleepiness, it is better to use morning bright light and perhaps a lower dose of melatonin.
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影响因子：
2.2
作者：
AKERSTEDT, T;GILLBERG, M
通讯作者：
GILLBERG, M
DOI：
10.3758/bf03200977
发表时间：
1985-12-01
期刊：
BEHAVIOR RESEARCH METHODS INSTRUMENTS & COMPUTERS
影响因子：
--
作者：
DINGES, DF;POWELL, JW
通讯作者：
POWELL, JW
影响因子：
2.5
作者：
DEACON, S;ENGLISH, J;ARENDT, J
通讯作者：
ARENDT, J
影响因子：
2.9
作者：
DEACON, S;ARENDT, J
通讯作者：
ARENDT, J
影响因子：
2.8
作者：
Eastman CI;Molina TA;Dziepak ME;Smith MR
通讯作者：
Smith MR