The M-superfamily of conotoxins: a review.

The M-superfamily of conotoxins: a review.
复制标题

DOI:
10.1007/s00018-009-0125-0
复制
发表时间:
2010-01
影响因子:
8
通讯作者:
McDougal, Owen M.
McDougal, Owen M.
中科院分区:
生物学1区
文献类型:
--
作者:
Jacob, Reed B.;McDougal, Owen M.

文献摘要

参考文献

被引文献

相似文献

本综述的重点是芋螺毒液肽的 M 超家族。属于 M 超家族的富含二硫键的肽具有三个环区域和半胱氨酸排列:CC-C-C-CC,其中破折号分别代表环一、二和三。 M 超家族肽的表征表明,即使半胱氨酸模式保持一致,肽的不同分支之间也会出现胱氨酸连接的多样性。根据第三个环区中第四个和第五个半胱氨酸残基之间的残基数量,该超家族细分为五个分支,M-1 到 M-5。 M 超家族肽似乎在芋螺毒液中普遍存在。它们的本土生物功能在很大程度上是无法解释的,它们代表了科学界的一个活跃的研究领域。
The focus of this review is the M-superfamily of Conus venom peptides. Disulfide rich peptides belonging to the M-superfamily have three loop regions and the cysteine arrangement: CC–C–C–CC, where the dashes represent loops one, two, and three, respectively. Characterization of M-superfamily peptides has demonstrated that diversity in cystine connectivity occurs between different branches of peptides even though the cysteine pattern remains consistent. This superfamily is subdivided into five branches, M-1 through M-5, based on the number of residues in the third loop region, between the fourth and fifth cysteine residues. M-superfamily peptides appear to be ubiquitous in Conus venom. They are largely unexplained in indigenous biological function, and they represent an active area of research within the scientific community.
DOI: 10.1111/j.1742-4658.2007.05795.x
发表时间: 2007-05-01
期刊: FEBS JOURNAL
影响因子: 5.4
作者:
Du, Wei-Hong;Han, Yu-Hong;Fang, Wei-Hai
通讯作者: Fang, Wei-Hai
DOI: 10.1074/jbc.c900990199
发表时间: 2000-08-11
影响因子: 4.8
作者:
Jacobsen, RB;Koch, ED;Terlau, H
通讯作者: Terlau, H
DOI: 10.1007/978-3-540-30880-5_4
发表时间: 2006-01-01
期刊: MOLLUSCS: FROM CHEM-ECOLOGICAL STUDY TO BIOTECHNOLOGICAL APPLICATION
影响因子: --
作者:
Franco, A.;Pisarewicz, K.;Mari, F.
通讯作者: Mari, F.
DOI: 10.1016/0041-0101(81)90106-9
发表时间: 1981-01-01
期刊: TOXICON
影响因子: 2.8
作者:
CLARK, C;OLIVERA, BM;CRUZ, LJ
通讯作者: CRUZ, LJ
DOI: 10.1021/bi960073o
发表时间: 1996-07-09
期刊: BIOCHEMISTRY
影响因子: 2.9
作者:
Hill, JM;Alewood, PF;Craik, DJ
通讯作者: Craik, DJ