Nonoverlapping sets of synapses drive on responses and off responses in auditory cortex.
Nonoverlapping sets of synapses drive on responses and off responses in auditory cortex.
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DOI：
10.1016/j.neuron.2010.01.020
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发表时间：
2010-02-11
期刊：
影响因子：
16.2
通讯作者：
Wehr M
中科院分区：
文献类型：
--
作者：
Scholl B;Gao X;Wehr M
视觉、体感觉和听觉皮层中的神经元可以对感觉刺激的开始和结束作出反应。在听觉皮层中，这些关闭反应可能是听觉系统使用声音偏移作为感知分组线索的能力的基础。Off反应被广泛认为是由抑制后反弹引起的，但这一假设从未被直接验证过。我们使用体内全细胞记录来测量声音诱发的突触抑制。我们发现抑制总是短暂的，表明关闭反应不是由听觉皮层神经元的抑制后反弹引起的。相反，打开和关闭反应似乎是由不同的突触组驱动的，因为它们有不同的频率调节和不同的兴奋-抑制平衡。此外，开-开序列导致完全正向抑制，而关-开序列根本不导致任何抑制。我们的结论是，打开和关闭的反应是由大部分不重叠的突触输入集驱动的。
Neurons in visual, somatosensory, and auditory cortex can respond to the termination as well as the onset of a sensory stimulus. In auditory cortex, these off responses may underlie the ability of the auditory system to use sound offsets as cues for perceptual grouping. Off responses have been widely proposed to arise from postinhibitory rebound, but this hypothesis has never been directly tested. We used in vivo whole-cell recordings to measure the synaptic inhibition evoked by sound onset. We find that inhibition is invariably transient, indicating that off responses are not caused by post-inhibitory rebound in auditory cortical neurons. Instead, on and off responses appear to be driven by distinct sets of synapses, because they have distinct frequency tuning and different excitatory-inhibitory balance. Furthermore, an on-on sequence causes complete forward suppression, whereas an off-on sequence causes no suppression at all. We conclude that on and off responses are driven by largely nonoverlapping sets of synaptic inputs.
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