Forced expiratory volume in 1 second and cognitive aging in men.
Forced expiratory volume in 1 second and cognitive aging in men.
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DOI：
10.1111/j.1532-5415.2011.03487.x
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发表时间：
2011-07
影响因子：
6.3
通讯作者：
Litonjua AA
中科院分区：
文献类型：
--
作者：
Weuve J;Glymour MM;Hu H;Sparrow D;Spiro A 3rd;Vokonas PS;Litonjua AA
评估老年男性1秒用力呼气量(FEV1，一种整体肺功能的指标)、长期平均FEV1以及FEV1下降率与认知和认知功能下降的关系。前瞻性观察性研究。以社区为基础的人口。来自标准老龄化研究的864名老年男性。从1984年开始，参与者每三年进行一次临床评估。肺功能评估提供了FEV1的估计。认知评估开始于1993年，需要对几种认知能力进行测试。在基线认知测试前大约12年测量FEV1，12年期间的平均FEV1，以及FEV1的变化率都是根据基线和认知测试中的表现变化进行评估的。在多变量调整的分析中，FEV1和基线认知分数之间的联系是混合的，尽管平均FEV1预测在视觉空间能力(P=0.04)和一般认知(P=0.03)测试中的表现明显更好。FEV1越高，认知功能下降越慢，但只有既往FEV1与注意力之间的关联显著(FEV1的标准差=0.056，P=0.05)。FEV1下降的速度与认知功能或下降的关系并不一致。在从不吸烟的男性中，研究结果大致相似或更强。为了解释选择性自然减员造成的潜在偏差，审查权重的逆概率被应用于认知衰退分析，产生的估计略大；审查模型的预测能力不足限制了这种方法。总体而言，这些数据提供的证据有限，表明FEV1与认知老化之间存在负相关。
To evaluate forced expiratory volume in 1 second (FEV1, a measure of overall lung function), long-term average FEV1, and rate of decline in FEV1 in relation to cognition and cognitive decline in older men. Prospective observational study. Community-based population. Eight hundred sixty-four older men from the Normative Aging Study. Starting in 1984, participants underwent triennial clinical evaluations. Lung function assessments provided estimates of FEV1. Cognitive assessments entailing tests of several cognitive abilities began in 1993. FEV1 measured approximately 12 years before baseline cognitive testing, average FEV1 over the 12-year period, and rate of change in FEV1 were all evaluated in relation to baseline and change in performance on the cognitive tests. In multivariable-adjusted analyses, associations between FEV1 and baseline cognitive scores were mixed, although average FEV1 predicted significantly better performance on tests of visuospatial ability (P =.04) and general cognition (P =.03). Higher FEV1 was more consistently associated with slower cognitive decline, but only the association between historical FEV1 and attention was significant (difference per standard deviation in FEV1 = 0.056, P =.05). Rate of FEV1 decline was not consistently associated with cognitive function or decline. Findings were generally similar or stronger in men who had never smoked. To account for potential bias due to selective attrition, inverse probability of censoring weights were applied to the cognitive decline analyses, yielding slightly larger estimates; the inadequate prognostic power of the censoring models limited this approach. Overall, the data provide limited evidence of an inverse association between FEV1 and cognitive aging.
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影响因子：
39.2
作者：
Agnarsson, U;Thorgeirsson, G;Sigfusson, N
通讯作者：
Sigfusson, N
影响因子：
5
作者：
COOK, NR;EVANS, DA;TAYLOR, JO
通讯作者：
TAYLOR, JO
影响因子：
3.7
作者：
Albert, MS;Savage, CR;Rowe, JW
通讯作者：
Rowe, JW
影响因子：
5
作者：
Cole, Stephen R.;Hernan, Miguel A.
通讯作者：
Hernan, Miguel A.
DOI：
10.1111/j.1532-5415.2004.52407.x
发表时间：
2004-09-01
影响因子：
6.3
作者：
Chodosh, J;Seeman, TE;Reuben, DB
通讯作者：
Reuben, DB