Diverse functions of miR-125 family in different cell contexts.
Diverse functions of miR-125 family in different cell contexts.
复制标题
miR-125家族在不同细胞环境中的不同功能
DOI：
10.1186/1756-8722-6-6
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发表时间：
2013-01-15
影响因子：
28.5
通讯作者：
Chen YQ
中科院分区：
文献类型：
--
作者：
Sun YM;Lin KY;Chen YQ
microRNA（miRNAs）是一类在转录后水平调控基因表达的新型非编码RNA分子。迄今为止，在人类细胞中已经鉴定出超过1000种miRNAs，并且据报道它们在正常细胞稳态、细胞转移和疾病的发病和进展中起重要作用。miR-125是从线虫到人类的多种物种中高度保守的miRNA，由三种同源物hsa-miR-125 a、hsa-miR-125 b-1和hsa-miR-125-2组成。该家族的成员已被证实是下调的，在许多不同类型的疾病中表现出其疾病抑制特性，同时它们在某些情况下也具有疾病促进功能。MiR-125靶向转录因子、基质金属蛋白酶、Bcl-2家族成员等多个基因，这些基因的异常可导致细胞的异常增殖、转移和侵袭，甚至肿瘤。此外，miR-125在免疫宿主防御中起着至关重要的作用，特别是在对细菌或病毒感染的应答中。本文就miR-125家族在肿瘤和宿主免疫反应中的作用进行综述。我们还讨论了该miRNA家族作为未来不同疾病的有希望的生物标志物和治疗靶点的潜力。
MicroRNAs (miRNAs) are emerging as a novel class of non-coding RNA molecules that regulate gene expression at a post-transcriptional level. More than 1000 miRNAs have been identified in human cells to date, and they are reported to play important roles in normal cell homeostasis, cell metastasis and disease pathogensis and progression. MiR-125, which is a highly conserved miRNA throughout diverse species from nematode to humans, consists of three homologs hsa-miR-125a, hsa-miR-125b-1 and hsa-miR-125-2. Members of this family have been validated to be down-regulated, exhibiting its disease-suppressing properties in many different types of diseases, while they also have disease-promoting functions in certain contexts. MiR-125 targets a number of genes such as transcription factors, matrix-metalloprotease, members of Bcl-2 family and others, aberrance of which may lead to abnormal proliferation, metastasis and invasion of cells, even carcinomas. Furthermore, miR-125 plays a crucial role in immunological host defense, especially in response to bacterial or viral infections. In this review, we summarize the implication of miR-125 family in disease suppression and promotion, focusing on carcinoma and host immune responses. We also discussed the potential of this miRNA family as promising biomarkers and therapeutic targets for different diseases in future.
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影响因子：
4.1
作者：
Guo X;Wu Y;Hartley RS
通讯作者：
Hartley RS
DOI：
10.1083/jcb.201007165
发表时间：
2011-01-10
期刊：
The Journal of cell biology
影响因子：
--
作者：
Ge Y;Sun Y;Chen J
通讯作者：
Chen J
影响因子：
28.5
作者：
Faraoni I;Laterza S;Ardiri D;Ciardi C;Fazi F;Lo-Coco F
通讯作者：
Lo-Coco F
DOI：
10.1002/gcc.20808
发表时间：
2010-11
期刊：
Genes, chromosomes & cancer
影响因子：
--
作者：
Cortez MA;Nicoloso MS;Shimizu M;Rossi S;Gopisetty G;Molina JR;Carlotti C Jr;Tirapelli D;Neder L;Brassesco MS;Scrideli CA;Tone LG;Georgescu MM;Zhang W;Puduvalli V;Calin GA
通讯作者：
Calin GA
影响因子：
5.5
作者：
Huang, Hsin-Chun;Yu, Hong-Ren;Yang, Kuender D.
通讯作者：
Yang, Kuender D.