Long-term cancer risk in women given diethylstilbestrol (DES) during pregnancy.
Long-term cancer risk in women given diethylstilbestrol (DES) during pregnancy.
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DOI：
10.1054/bjoc.2000.1521
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发表时间：
2001-01-05
影响因子：
8.8
通讯作者：
Hartge P
中科院分区：
文献类型：
--
作者：
Titus-Ernstoff L;Hatch EE;Hoover RN;Palmer J;Greenberg ER;Ricker W;Kaufman R;Noller K;Herbst AL;Colton T;Hartge P
从1940年到1960年代，已烯雌酚（DES），一种合成雌激素，被给予孕妇，以防止妊娠并发症和损失。随后的研究表明，暴露于此的女儿生殖道异常，特别是阴道腺癌的风险增加。一些研究还发现，接触DES的母亲患乳腺癌的风险增加。在这份报告中，我们提出了进一步的后续行动和合并分析的两个队列的妇女谁暴露于DES在怀孕期间。我们研究的目的是评估母体DES暴露与癌症风险的关系，特别是与激素病因有关的肿瘤。通过审查母亲研究队列的医疗记录或Dieckmann研究的临床试验记录确定DES暴露状态。Poisson回归分析用于估计DES与癌症发生之间关系的相对风险（RR）和95%置信区间（CI）。研究结果表明DES暴露与乳腺癌风险之间存在中度相关性，RR = 1.27（95%CI = 1.07-1.52）。乳腺癌家族史、口服避孕药或激素替代疗法的使用不会加剧风险的增加。我们没有发现DES与卵巢癌、子宫内膜癌或其他癌症风险相关的证据。© 2001年癌症研究运动http://www.bjcancer.com
From 1940 through the 1960s, diethylstilbestrol (DES), a synthetic oestrogen, was given to pregnant women to prevent pregnancy complications and losses. Subsequent studies showed increased risks of reproductive tract abnormalities, particularly vaginal adenocarcinoma, in exposed daughters. An increased risk of breast cancer in the DES-exposed mothers was also found in some studies. In this report, we present further follow-up and a combined analysis of two cohorts of women who were exposed to DES during pregnancy. The purpose of our study was to evaluate maternal DES exposure in relation to risk of cancer, particularly tumours with a hormonal aetiology. DES exposure status was determined by a review of medical records of the Mothers Study cohort or clinical trial records of the Dieckmann Study. Poisson regression analyses were used to estimate relative risks (RR) and 95% confidence intervals (CI) for the relationship between DES and cancer occurrence. The study results demonstrated a modest association between DES exposure and breast cancer risk, RR = 1.27 (95% CI = 1.07–1.52). The increased risk was not exacerbated by a family history of breast cancer, or by use of oral contraceptives or hormone replacement therapy. We found no evidence that DES was associated with risk of ovarian, endometrial or other cancer. © 2001 Cancer Research Campaign http://www.bjcancer.com
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影响因子：
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作者：
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