Modulation of host responses by oral commensal bacteria.
Modulation of host responses by oral commensal bacteria.
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DOI：
10.3402/jom.v7.26941
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发表时间：
2015
影响因子：
4.5
通讯作者：
Meade J
中科院分区：
文献类型：
--
作者：
Devine DA;Marsh PD;Meade J
免疫调节共生细菌被认为对于维持健康组织至关重要，具有多种作用，包括启动免疫反应以确保快速有效地防御病原体。口腔组织（如肠道）的默认状态是一种炎症状态，可以通过调节机制和抗炎常驻细菌的活性来平衡，这些细菌调节 Toll 样受体 (TLR) 信号传导或 NF-κB 激活，或影响免疫细胞的发育和活动。然而，正常常驻生物体抑制炎症的广泛能力可能会给免疫系统带来不可持续的负担，并损害对病原体的反应。免疫抑制常驻细菌已从口腔中分离出来，例如，可能占菌斑或舌头上常驻链球菌的 30%。它们在口腔健康和生态失调中的作用仍有待确定。多种细菌成分和/或产品可以介导免疫调节活性，从而提高了使用益生菌、益生元或共生源免疫调节分子开发替代治疗和健康促进策略的可能性。
Immunomodulatory commensal bacteria are proposed to be essential for maintaining healthy tissues, having multiple roles including priming immune responses to ensure rapid and efficient defences against pathogens. The default state of oral tissues, like the gut, is one of inflammation which may be balanced by regulatory mechanisms and the activities of anti-inflammatory resident bacteria that modulate Toll-like receptor (TLR) signalling or NF-κB activation, or influence the development and activities of immune cells. However, the widespread ability of normal resident organisms to suppress inflammation could impose an unsustainable burden on the immune system and compromise responses to pathogens. Immunosuppressive resident bacteria have been isolated from the mouth and, for example, may constitute 30% of the resident streptococci in plaque or on the tongue. Their roles in oral health and dysbiosis remain to be determined. A wide range of bacterial components and/or products can mediate immunomodulatory activity, raising the possibility of development of alternative strategies for therapy and health promotion using probiotics, prebiotics, or commensal-derived immunomodulatory molecules.
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影响因子：
30.5
作者：
通讯作者：
--
影响因子：
--
作者：
Rizzello V;Bonaccorsi I;Dongarrà ML;Fink LN;Ferlazzo G
通讯作者：
Ferlazzo G
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K
影响因子：
4.3
作者：
Faust K;Sathirapongsasuti JF;Izard J;Segata N;Gevers D;Raes J;Huttenhower C
通讯作者：
Huttenhower C
影响因子：
7.6
作者：
Irie, K.;Novince, C. M.;Darveau, R. P.
通讯作者：
Darveau, R. P.