Effects of chronic noise exposure on the microbiome-gut-brain axis in senescence-accelerated prone mice: implications for Alzheimer's disease.
Effects of chronic noise exposure on the microbiome-gut-brain axis in senescence-accelerated prone mice: implications for Alzheimer's disease.
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慢性噪声暴露对加速衰老小鼠微生物群-肠-脑轴的影响：对阿尔茨海默病的影响
DOI：
10.1186/s12974-018-1223-4
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发表时间：
2018-06-22
影响因子：
9.3
通讯作者：
Zhai Q
中科院分区：
文献类型：
--
作者：
Cui B;Su D;Li W;She X;Zhang M;Wang R;Zhai Q
长期接触噪音与神经炎症和肠道微生物群失调有关，并会增加患阿尔茨海默病 (AD) 的风险。环境危害也被认为与增加 AD 发病机制的遗传易感性因素有关。然而，关于慢性噪音应激与微生物组-肠-脑轴改变之间的联系的实验证据有限，这可能与 AD 的发展密切相关。本研究的目的是系统地研究慢性噪声暴露对衰老加速小鼠 pron 8 (SAMP8) 品系微生物组-肠-脑轴的影响。我们建立了 SAMP8 小鼠模型来研究噪声暴露对微生物组-肠-脑轴的影响。海马β淀粉样蛋白（Aβ）评估和Morris水迷宫用于评估AD样变化，16S核糖体RNA测序分析用于肠道菌群测量，并评估内皮紧密连接和血清神经递质和炎症介质水平，以及粪便微生物群移植，以探讨潜在的病理机制。慢性噪声暴露会导致年轻 SAMP8 小鼠的认知障碍和 Aβ 积累，与老年 SAMP8 小鼠中观察到的情况类似。噪音暴露还与肠道微生物群多样性下降和成分改变有关。 Axis系列研究表明，在暴露于慢性噪音的年轻SAMP8小鼠中，肠道和大脑中的内皮紧密连接蛋白均减少，而血清神经递质和炎症介质水平升高，与衰老组中的观察结果相似。通过微生物移植实验进一步证实了肠道细菌在噪声暴露引起的上皮完整性损伤和 Aβ 积累中的重要性。此外，慢性噪音的影响通常与强度有关。慢性噪音暴露改变了肠道微生物群，加速了与年龄相关的神经化学和炎症失调，并促进了 SAMP8 小鼠大脑中类似 AD 的变化。本文的在线版本 (10.1186/s12974-018-1223-4) 包含补充材料，可供授权用户使用。
Chronic noise exposure is associated with neuroinflammation and gut microbiota dysregulation and increases the risk of Alzheimer’s disease (AD). Environmental hazards are also thought to be associated with genetic susceptibility factors that increase AD pathogenesis. However, there is limited experimental evidence regarding the link between chronic noise stress and microbiome-gut-brain axis alterations, which may be closely related to AD development. The aim of the present study was to systematically investigate the effects of chronic noise exposure on the microbiome-gut-brain axis in the senescence-accelerated mouse prone 8 (SAMP8) strain. We established SAMP8 mouse models to examine the consequences of noise exposure on the microbiome-gut-brain axis. Hippocampal amyloid-β (Aβ) assessment and the Morris water maze were used to evaluate AD-like changes, 16S ribosomal RNA sequencing analyses were used for intestinal flora measurements, and assessment of endothelial tight junctions and serum neurotransmitter and inflammatory mediator levels, as well as fecal microbiota transplant, was conducted to explore the underlying pathological mechanisms. Chronic noise exposure led to cognitive impairment and Aβ accumulation in young SAMP8 mice, similar to that observed in aging SAMP8 mice. Noise exposure was also associated with decreased gut microbiota diversity and compositional alterations. Axis-series studies showed that endothelial tight junction proteins were decreased in both the intestine and brain, whereas serum neurotransmitter and inflammatory mediator levels were elevated in young SAMP8 mice exposed to chronic noise, similar to the observations made in the aging group. The importance of intestinal bacteria in noise exposure-induced epithelial integrity impairment and Aβ accumulation was further confirmed through microbiota transplantation experiments. Moreover, the effects of chronic noise were generally intensity-dependent. Chronic noise exposure altered the gut microbiota, accelerated age-related neurochemical and inflammatory dysregulation, and facilitated AD-like changes in the brain of SAMP8 mice. The online version of this article (10.1186/s12974-018-1223-4) contains supplementary material, which is available to authorized users.
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影响因子：
3.7
作者：
Biagi E;Nylund L;Candela M;Ostan R;Bucci L;Pini E;Nikkïla J;Monti D;Satokari R;Franceschi C;Brigidi P;De Vos W
通讯作者：
De Vos W
DOI：
10.1016/s0140-6736(20)32205-4
发表时间：
2021-04-24
期刊：
Lancet (London, England)
影响因子：
--
作者：
Scheltens P;De Strooper B;Kivipelto M;Holstege H;Chételat G;Teunissen CE;Cummings J;van der Flier WM
通讯作者：
van der Flier WM
影响因子：
64.8
作者：
Gandy, Sam
通讯作者：
Gandy, Sam
影响因子：
16.2
作者：
Cappuccio FP;D'Elia L;Strazzullo P;Miller MA
通讯作者：
Miller MA
慢性噪音暴露导致大鼠海马和前额叶皮层 Tau 蛋白过度磷酸化持续存在以及 NFT Tau 蛋白的形成
影响因子：
5.3
作者：
Cui, Bo;Zhu, Lixing;Liu, Hongtao
通讯作者：
Liu, Hongtao