Extended Middle Cerebral Artery Occlusion (MCAO) Model to Mirror Stroke Patients Undergoing Thrombectomy.
Extended Middle Cerebral Artery Occlusion (MCAO) Model to Mirror Stroke Patients Undergoing Thrombectomy.
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DOI：
10.1007/s12975-021-00936-y
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发表时间：
2022-08
影响因子：
6.9
通讯作者：
Pennypacker KR
中科院分区：
文献类型：
--
作者：
Messmer SJ;Salmeron KE;Frank JA;McLouth CJ;Lukins DE;Hammond TC;Lin AL;Fraser JF;Pennypacker KR
中风仍然是全球主要的死亡和残疾原因。在过去的十年中，机械血栓清除的治疗窗口已经从最多6小时增加到24小时甚至更长。虽然血管内技术的进步提高了血管再通率，但没有一种卒中后药物疗法能有效地促进神经修复和恢复。需要新的实验模型来更接近地模拟人类患者。我们团队建立了一种大鼠短暂性5小时闭塞的模型，以模拟中风患者接受血栓切除的情况。我们的程序是专门为老年大鼠设计的，并根据性别进行了优化，以使老年雄性和雌性大鼠的死亡率和损伤程度保持一致。该模型采用了以美国国立卫生研究院中风量表为模型的神经学评估。最后，通过比较关键炎症基因的基因表达，评估了我们的卒中大鼠模型和人类之间的翻译潜力。该模型将有助于评估血栓清除过程中大血管闭塞的辅助治疗的治疗靶点。
Stroke remains a leading global cause of death and disability. In the last decade, the therapeutic window for mechanical thrombectomy has increased from a maximum of 6 hours to 24 hours and beyond. While endovascular advancements have improved rates of recanalization, no post-stroke pharmacotherapeutics have been effective in enhancing neurorepair and recovery. New experimental models are needed to closer mimic the human patient. Our group has developed a model of transient 5-hour occlusion in rats to mimic stroke patients undergoing thrombectomy. Our procedure was designed specifically in aged rats and was optimized based on sex in order to keep mortality and extent of injury consistent between aged male and female rats. This model uses a neurological assessment modeled after the NIH Stroke Scale. Finally, the potential for translation between our rat model of stroke and humans was assessed using comparative gene expression for key inflammatory genes. This model will be useful in the evaluation of therapeutic targets to develop adjuvant treatments for large vessel occlusion during the thrombectomy procedure.
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影响因子：
4
作者：
Bishop, Kathleen A.;Wang, Xiaohua;Coy, Heidi M.;Meyer, Mark B.;Gumperz, Jenny E.;Pike, J. Wesley
通讯作者：
Pike, J. Wesley
影响因子：
4.5
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5.3
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通讯作者：
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影响因子：
2
作者：
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通讯作者：
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影响因子：
6.3
作者：
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通讯作者：
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