Serum selenoprotein P, but not selenium, predicts future hyperglycemia in a general Japanese population.
Serum selenoprotein P, but not selenium, predicts future hyperglycemia in a general Japanese population.
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DOI：
10.1038/s41598-018-35067-2
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发表时间：
2018-11-13
影响因子：
4.6
通讯作者：
Takamura T
中科院分区：
文献类型：
--
作者：
Oo SM;Misu H;Saito Y;Tanaka M;Kato S;Kita Y;Takayama H;Takeshita Y;Kanamori T;Nagano T;Nakagen M;Urabe T;Matsuyama N;Kaneko S;Takamura T
我们的目的是检验以下假设：硒蛋白 P (SELENOP) 是一种肝因子，与小鼠胰岛素抵抗和胰岛素产生受损的发展有关，与人类未来高血糖的发生有关。 76 名没有糖尿病的健康非妊娠人类受试者在基线和 4 年随访时接受了口服葡萄糖耐量试验 (OGTT)。 9 名受试者在随访中出现糖耐量受损或 2 型糖尿病。在基线时，SELENOP 浓度与胰岛素生成指数呈负相关，但与稳态模型评估估计的胰岛素抵抗 (HOMA-IR) 无关。多变量分析表明，基线 SELENOP 独立于其他参数预测随访时的空腹血糖。受试者工作特征 (ROC) 曲线分析表明，血清 SELENOP（而非硒）的基线浓度是预测未来葡萄糖耐受不良发生的可靠测试。总之，循环中 SELENOP 的升高（而非循环中硒的升高）与一般日本人群中未来发生的葡萄糖耐受不良呈正相关且独立相关。
We aimed to test the hypothesis that selenoprotein P (SELENOP), a hepatokine involved in the development of both insulin resistance and impaired insulin production in mice, is related to future onset of hyperglycemia in humans. 76 healthy non-pregnant human subjects without diabetes underwent oral glucose tolerance test (OGTT) at baseline and 4-years follow-up. Nine subjects developed either impaired glucose tolerance or type 2 diabetes at follow-up. At baseline, SELENOP concentrations correlated negatively with insulinogenic index, but not with homeostasis model assessment-estimated insulin resistance (HOMA-IR). Multivariate analysis showed that baseline SELENOP predicted fasting plasma glucose at follow-up independently of the other parameters. The receiver operating characteristic (ROC) curve analysis showed that baseline concentrations of serum SELENOP, but not of selenium, were a reliable test to predict future onset of glucose intolerance. In conclusion, elevation of circulating SELENOP, but not of circulating selenium, was positively and independently associated with future onset of glucose intolerance in a general Japanese population.
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影响因子：
16.2
作者：
通讯作者：
--
影响因子：
56.9
作者：
Kryukov, GV;Castellano, S;Gladyshev, VN
通讯作者：
Gladyshev, VN
影响因子：
7.7
作者：
Bock, Gerlies;Chittilapilly, Elizabeth;Rizza, Robert A.
通讯作者：
Rizza, Robert A.
DOI：
10.1297/cpe.27.67
发表时间：
2018
期刊：
Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology
影响因子：
--
作者：
Kawai M;Shoji Y;Onuma S;Etani Y;Ida S
通讯作者：
Ida S
影响因子：
5.1
作者：
Fukushima, M;Suzuki, H;Seino, Y
通讯作者：
Seino, Y