Birth outcomes and maternal residential proximity to natural gas development in rural Colorado.
Birth outcomes and maternal residential proximity to natural gas development in rural Colorado.
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DOI：
10.1289/ehp.1306722
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发表时间：
2014-04
影响因子：
10.4
通讯作者：
Adgate JL
中科院分区：
文献类型：
--
作者：
McKenzie LM;Guo R;Witter RZ;Savitz DA;Newman LS;Adgate JL
背景：出生缺陷是新生儿死亡的主要原因。天然气开发（NGD）释放出几种潜在的致畸物质，美国的天然气产量正在扩大。目的：我们对1996年至2009年在科罗拉多农村出生的124,842名产妇进行了回顾性队列研究，研究了产妇居住地与NGD的接近程度与出生结局之间的关系。研究方法：我们计算了母亲居住地10英里半径内的距离加权天然气井数，以估计母亲对NGD的暴露。Logistic回归，调整了母亲和婴儿的协变量，用于估计与暴露三分位数的先天性心脏病（CHD），神经管缺陷（NTD），唇裂，早产，足月低出生体重。使用多元线性回归研究与足月出生体重的相关性。结果如下：CHD患病率随暴露三分位数增加而增加，最高三分位数的比值比（OR）为1.3（95% CI：1.2，1.5）; NTD患病率与最高三分位数的暴露相关（OR = 2.0; 95% CI：1.0，3.9，基于59例病例），相比之下，在10英里半径内没有任何气体威尔斯。暴露与早产呈负相关，与胎儿生长呈正相关，尽管相关程度很小。没有发现暴露和口腔裂缝之间的关联。结论：在这个大的队列中，我们观察到在母亲居住的10英里半径内天然气威尔斯井的密度和接近程度与CHD和可能的NTD的患病率之间的关联。为了进一步探讨这些关联，需要在暴露估计中有更大的特异性。引文：McKenzie LM，Guo R，Witter RZ，Savitz DA，纽曼LS，Adgate JL。2014.科罗拉多农村地区天然气开发的分娩结果和产妇住宅接近度环境健康展望122：412 - 417; http：//www.example.com
Background: Birth defects are a leading cause of neonatal mortality. Natural gas development (NGD) emits several potential teratogens, and U.S. production of natural gas is expanding. Objectives: We examined associations between maternal residential proximity to NGD and birth outcomes in a retrospective cohort study of 124,842 births between 1996 and 2009 in rural Colorado. Methods: We calculated inverse distance weighted natural gas well counts within a 10-mile radius of maternal residence to estimate maternal exposure to NGD. Logistic regression, adjusted for maternal and infant covariates, was used to estimate associations with exposure tertiles for congenital heart defects (CHDs), neural tube defects (NTDs), oral clefts, preterm birth, and term low birth weight. The association with term birth weight was investigated using multiple linear regression. Results: Prevalence of CHDs increased with exposure tertile, with an odds ratio (OR) of 1.3 for the highest tertile (95% CI: 1.2, 1.5); NTD prevalence was associated with the highest tertile of exposure (OR = 2.0; 95% CI: 1.0, 3.9, based on 59 cases), compared with the absence of any gas wells within a 10-mile radius. Exposure was negatively associated with preterm birth and positively associated with fetal growth, although the magnitude of association was small. No association was found between exposure and oral clefts. Conclusions: In this large cohort, we observed an association between density and proximity of natural gas wells within a 10-mile radius of maternal residence and prevalence of CHDs and possibly NTDs. Greater specificity in exposure estimates is needed to further explore these associations. Citation: McKenzie LM, Guo R, Witter RZ, Savitz DA, Newman LS, Adgate JL. 2014. Birth outcomes and maternal residential proximity to natural gas development in rural Colorado. Environ Health Perspect 122:412–417; http://dx.doi.org/10.1289/ehp.1306722
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