Measuring natural selection on genotypes and phenotypes in the wild.
Measuring natural selection on genotypes and phenotypes in the wild.
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DOI:
10.1101/sqb.2009.74.045
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发表时间:
2009
期刊:
影响因子:
--
通讯作者:
Hoekstra HE
中科院分区:
文献类型:
--
作者:
Linnen CR;Hoekstra HE
A complete understanding of the role of natural selection in driving evolutionary change requires accurate estimates of the strength of selection acting in the wild. Accordingly, several approaches utilizing a variety of data—including patterns of DNA variability, spatial and temporal changes in allele frequencies, and fitness estimates—have been developed to identify and quantify selection on both genotypes and phenotypes. Here, we review these approaches, drawing on both recent and classic examples to illustrate their utility and limitations. We then argue that by combining estimates of selection at multiple levels—from individual mutations to phenotypes—and at multiple timescales—from ecological to evolutionary—with experiments that demonstrate why traits are under selection, we can gain a much more complete picture of the adaptive process.
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