Deciphering the bacterial glycocode: recent advances in bacterial glycoproteomics.
Deciphering the bacterial glycocode: recent advances in bacterial glycoproteomics.
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DOI:
10.1016/j.cbpa.2012.12.006
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发表时间:
2013-02
影响因子:
7.8
通讯作者:
Dube, Danielle H.
中科院分区:
文献类型:
--
作者:
Longwell, Scott A.;Dube, Danielle H.
Bacterial glycoproteins represent an attractive target for new antibacterial treatments, as they are frequently linked to pathogenesis and contain distinctive glycans that are absent in humans. Despite their potential therapeutic importance, many bacterial glycoproteins remain uncharacterized. This review focuses on recent advances in deciphering the bacterial glycocode, including metabolic glycan labeling to discover and characterize bacterial glycoproteins, lectin-based microarrays to monitor bacterial glycoprotein dynamics, crosslinking sugars to assess the roles of bacterial glycoproteins, and harnessing bacterial glycosylation systems for the efficient production of industrially important glycoproteins.
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