The derived neutrophil to lymphocyte ratio is an independent prognostic factor in patients with diffuse large B-cell lymphoma.
The derived neutrophil to lymphocyte ratio is an independent prognostic factor in patients with diffuse large B-cell lymphoma.
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DOI：
10.1038/bjc.2013.763
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发表时间：
2014-01-21
影响因子：
8.8
通讯作者：
Pichler, M.
中科院分区：
文献类型：
--
作者：
Troppan, K.;Deutsch, A.;Gerger, A.;Stojakovic, T.;Beham-Schmid, C.;Wenzl, K.;Neumeister, P.;Pichler, M.
随着越来越多的证据表明炎症在癌症生物学中的作用，全身炎症反应已被假定为在广泛的不同癌症类型中具有预后意义。最近，衍生的中性粒细胞与淋巴细胞的比率（dNLR）已被提出作为一个容易确定的预后因素在癌症患者。然而，其在弥漫性大B细胞淋巴瘤（DLBCL）患者中的预后意义从未被探讨过。回顾性评价了2004年至2013年在奥地利一家中心诊断的290例连续DLBCL患者的数据。采用Kaplan-Meier曲线分析dNLR和其他临床病理因素（包括年龄、乳酸脱氢酶、细胞来源分类和安阿伯分期）对5年总生存率（OS）和无病生存率（DFS）的预后影响。为了评价dNLR的独立预后相关性，应用单变量和多变量考克斯回归模型。在OS（HR=2.02，置信区间（CI）95%=1.17-3.50，P=0.011）和DFS（HR=2.15，CI 95%=1.04-4.47，P=0.038）的多变量分析中，确定了高dNLR与不良临床结局之间的独立显著相关性。在本研究中，我们发现诊断DLBCL时高dNLR是临床预后不良的独立因素。我们的数据鼓励在前瞻性研究中进一步验证这个容易获得的参数，并作为临床试验中的潜在分层工具。
With growing evidence on the role of inflammation in cancer biology, the systemic inflammatory response has been postulated as having prognostic significance in a wide range of different cancer types. Recently, the derived neutrophil to lymphocyte ratio (dNLR) has been proposed as an easily determinable prognostic factor in cancer patients. Nevertheless, its prognostic significance in diffuse large B-cell lymphoma (DLBCL) patients has never been explored. Data from 290 consecutive DLBCL patients, diagnosed between 2004 and 2013 at a single Austrian centre, were evaluated retrospectively. The prognostic influence of the dNLR and other clinico-pathological factors including age, lactate dehydrogenase, cell of origin category and Ann Arbor stage on 5-year overall- (OS) and disease-free (DFS) survival was studied by Kaplan–Meier curves. To evaluate the independent prognostic relevance of dNLR, univariate and multivariate Cox regression models were applied. An independent significant association between high dNLR and poor clinical outcome in multivariate analysis for OS (HR=2.02, confidence interval (CI) 95%=1.17–3.50, P=0.011), as well as DFS (HR=2.15, CI 95%=1.04–4.47, P=0.038), was identified. In the present study, we showed that a high dNLR at diagnosis of DLBCL represents an independent poor prognostic factor for clinical outcome. Our data encourage the further validation of this easily available parameter in prospective studies and as a potential stratification tool in clinical trials.
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DOI：
10.1073/pnas.0509182102
发表时间：
2005-12-20
影响因子：
11.1
作者：
Sato, E;Olson, SH;Odunsi, K
通讯作者：
Odunsi, K
影响因子：
8.8
作者：
Pichler M;Hutterer GC;Stoeckigt C;Chromecki TF;Stojakovic T;Golbeck S;Eberhard K;Gerger A;Mannweiler S;Pummer K;Zigeuner R
通讯作者：
Zigeuner R
影响因子：
64.8
作者：
Alizadeh, AA;Eisen, MB;Staudt, LM
通讯作者：
Staudt, LM
影响因子：
--
作者：
Cao, Ye;Shi, Yan-xia;Jiang, Wen-qi
通讯作者：
Jiang, Wen-qi
DOI：
10.1046/j.1365-2362.2003.01152.x
发表时间：
2003-05-01
影响因子：
5.5
作者：
Ribatti, D;Ennas, MG;Sirigu, P
通讯作者：
Sirigu, P