Hand grip strength and 2-minute walk test in chronic graft-versus-host disease assessment: analysis from the Chronic GVHD Consortium.
Hand grip strength and 2-minute walk test in chronic graft-versus-host disease assessment: analysis from the Chronic GVHD Consortium.
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DOI：
10.1016/j.bbmt.2013.03.014
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发表时间：
2013-06
影响因子：
4.3
通讯作者：
Lee, Stephanie J.
中科院分区：
文献类型：
--
作者：
Pidala, Joseph;Chai, Xiaoyu;Martin, Paul;Inamoto, Yoshihiro;Cutler, Corey;Palmer, Jeanne;Weisdorf, Daniel;Pavletic, Steven;Arora, Mukta;Jagasia, Madan;Jacobsohn, David;Lee, Stephanie J.
临床试验中，握力（HGS）和2分钟步行试验（2 MWT）已被提议作为慢性移植物抗宿主病（GVHD）评估的要素。使用所有可用数据（n=584次入组访视，1，689次随访访视，总计2，273次访视），我们从一项前瞻性观察性队列研究中探索了HGS和2 MWT与患者报告的测量值之间的关系。（Lee症状量表、SF-36和FACT-BMT生活质量量表以及人类活动概况或HAP）、慢性GVHD总体严重程度在多变量分析中，对显著协变量进行校正，以评估（NIH总体0 - 3分、临床医生总体0-3分和患者报告的总体0-3分）、计算的和临床医生报告的慢性GVHD应答和死亡率（总生存期（OS）、非复发死亡率（NRM）和无失败生存期（FFS））。2 MWT与Lee症状量表的直观领域（总体、皮肤、肺、能量）、SF-36领域和汇总评分、FACT汇总和领域评分以及HAP评分显著相关（所有p < 0.001）。与HGS的关联较少。2 MWT和HGS均与慢性GVHD严重程度显著相关。在多变量分析中，2 MWT与OS、NRM和FFS显著相关，而与HGS无关。2 MWT和HGS对NIH或临床医生报告的反应不敏感。基于与死亡率的独立相关性，这些数据支持2 MWT对于识别高风险慢性GVHD患者的重要性。然而，2 MWT的变化对慢性GVHD反应不敏感，限制了其在临床试验中的有用性。
Hand grip strength (HGS) and 2 minute walk test (2MWT) have been proposed as elements of chronic graft-vs-host disease (GVHD) assessment in clinical trials. Using all available data (n=584 enrollment visits, 1,689 follow-up visits, total of 2,273 visits) from a prospective observational cohort study, we explored the relationship between HGS and 2MWT and patient-reported measures (Lee symptom scale, SF-36 and FACT-BMT quality of life instruments, and Human Activity Profile, or HAP), chronic GVHD global severity (NIH global 0–3 score, clinician global 0–3 score, and patient-reported global 0–3 score), calculated and clinician-reported chronic GVHD response, and mortality (overall survival (OS), non-relapse mortality (NRM), and failure-free survival (FFS)) in multivariable analyses adjusted for significant covariates. 2MWT was significantly associated with intuitive domains of the Lee Symptom Scale (overall, skin, lung, energy), SF-36 domain and summary scores, FACT summary and domain scores, and HAP scores (all p < 0.001). Fewer associations were detected with the HGS. The 2MWT and HGS both had significant association with global chronic GVHD severity. In multivariable analysis, 2MWT was significantly associated with OS, NRM, and FFS, while no association was found for HGS. 2MWT and HGS were not sensitive to NIH or clinician-reported response. Based on independent association with mortality, these data support the importance of the 2MWT for identification of high-risk chronic GVHD patients. However, change in 2MWT is not sensitive to chronic GVHD response, limiting its usefulness in clinical trials.
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影响因子：
3
作者：
MCHORNEY, CA;WARE, JE;RACZEK, AE
通讯作者：
RACZEK, AE
DOI：
10.1053/bbmt.2002.v8.pm12234170
发表时间：
2002-01-01
影响因子：
4.3
作者：
Lee, SJ;Cook, EF;Antin, JH
通讯作者：
Antin, JH
影响因子：
4.3
作者：
Martin, PJ;Weisdorf, D;Lee, SJ
通讯作者：
Lee, SJ
DOI：
--
发表时间：
2020-07-01
期刊：
贵州民族研究
影响因子：
--
作者：
张湖婷
通讯作者：
--
影响因子：
20.3
作者：
Pidala, Joseph;Kurland, Brenda;Lee, Stephanie J.
通讯作者：
Lee, Stephanie J.