Peripheral monocyte count is an independent predictor of all-cause mortality in type 2 diabetes with macro-vascular complications
Peripheral monocyte count is an independent predictor of all-cause mortality in type 2 diabetes with macro-vascular complications
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外周单核细胞计数是伴有大血管并发症的 2 型糖尿病全因死亡率的独立预测因子
DOI：
10.1097/md.0000000000018876
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发表时间：
2020-01
期刊：
影响因子：
1.6
通讯作者：
Qifu Li
中科院分区：
文献类型：
--
作者：
Lina Yang;Jinbo Hu;Zhihong Wang;Xiangjun Chen;Yue Wang;Shumin Yang;Ting Luo;Mei;Qingfeng Cheng;Zhixin Xu;Zhipeng Du;Lilin Gong;Rong Luo;Qifu Li
摘要 单核细胞计数与死亡率之间的关系似乎在不同疾病中有所不同，但在 2 型糖尿病 (T2D) 中尚不清楚。我们进行了一项前瞻性研究，探讨单核细胞计数是否可以预测 2 型糖尿病患者的全因死亡率。在这项前瞻性研究中，基线时共有 1073 名 T2D 患者入组，其中 880 名患者完成了随访。中位随访时间为 47 个月。在基线时，记录临床特征，包括身高、体重、腰围、血压。测量生化参数，包括白细胞（WBCC）、中性粒细胞（NC）和单核细胞（MC）计数、血脂谱、糖化血红蛋白（HbA1c）、血清肌酐。查尔森合并症指数（CCI）是根据年龄和合并症计算的。根据基线 MC，参与者被分为低、中、高三分位数。使用回归模型分析外周 MC 与全因死亡率的关联。与存活的受试者相比，随访期间死亡的患者的基线MC显着较高（0.45±0.16 vs 0.37±0.15×109/L，P = .003）。在多变量 Cox 风险模型中，在对性别、体重指数、CCI、T2D 持续时间、病史进行调整后，较高 MC 三分位数的受试者显示出较高的全因死亡风险（以低三分位数为参考，中和高 MC 三分位数的风险比 [HR] 95%CI 分别为 2.65 [0.84,8.31] 和 3.73 [1.14,12.24]）。 高血压和代谢综合征、药物、高敏 C 反应蛋白水平、收缩压、HbA1c、WBCC 和 NC。在基线时患有大血管并发症的 T2D 患者中，MC 每增加 1-SD 就会导致全因死亡率风险增加 1.92 倍。然而，在基线时没有大血管并发症的受试者中，这种关系消失了（1.13 [0.72，1.78]，P = .591）。外周单核细胞计数是 T2D 全因死亡率的独立预测因子，特别是对于患有大血管并发症的受试者。
Abstract The relationship between monocyte count and mortality seemed to be varied in different diseases, and it remains unclear in type 2 diabetes (T2D). We conducted a prospective study to investigate whether monocyte count predict all-cause mortality in patients with T2D. In this prospective study, a total of 1073 patients with T2D were enrolled at baseline and 880 patients completed the follow up. The median follow-up time was 47 months. At baseline, clinical characteristics including height, weight, waist circumference, blood pressure were recorded. Biochemical parameters including counts of white blood cells (WBCC), neutrophil (NC) and monocyte (MC), lipid profiles, glycated hemoglobin (HbA1c), serum creatinine were measured. Charlson comorbidity index (CCI) was calculated based on age and comorbidities. Participants were stratified into low, median, and high tertiles according to the baseline MC. Regression models were used to analyze the associations of peripheral MC and the all-cause mortality. Compared to the survived subjects, the baseline MC was significantly higher in patients who deceased during the follow-up (0.45 ± 0.16 vs 0.37 ± 0.15 × 109/L, P = .003). In the multivariate Cox hazard models, subjects in higher MC tertile showed higher risks of all-cause mortality (low tertile as the reference, hazard ratio [HR] 95%CI 2.65 [0.84,8.31] and 3.73 [1.14,12.24] for middle and high MC tertile, respectively) after adjusted for gender, body mass index, CCI, duration of T2D, history of hypertension and metabolic syndrome, drugs, levels of high-sensitivity C-reactive protein, systolic blood pressure, HbA1c, WBCC, and NC. In T2D patients with macro-vascular complications at baseline, 1-SD increment of MC resulted in 1.92-fold higher risk of all-cause mortality. However, the relationship disappeared in subjects without macro-vascular complications at baseline (1.13 [0.72, 1.78], P = .591). Peripheral monocyte count is an independent predictor of all-cause mortality in T2D, especially for subjects with macro-vascular complications.
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影响因子：
4
作者：
Thygesen SK;Christiansen CF;Christensen S;Lash TL;Sørensen HT
通讯作者：
Sørensen HT
DOI：
10.29828/jfma.200311.0005
发表时间：
2003-11
期刊：
Journal of the Formosan Medical Association = Taiwan yi zhi
影响因子：
--
作者：
Zei-Shung Huang;K. Chien;Chi-Yu Yang;Chiu-Hwa Wang;Tien-Chun Chang;Chien-Jen Chen
通讯作者：
Zei-Shung Huang;K. Chien;Chi-Yu Yang;Chiu-Hwa Wang;Tien-Chun Chang;Chien-Jen Chen
影响因子：
4.7
作者：
Lee, Yoo-Young;Choi, Chel Hun;Bae, Duk-Soo
通讯作者：
Bae, Duk-Soo
影响因子：
120.7
作者：
Menke, Andy;Casagrande, Sarah;Cowie, Catherine C.
通讯作者：
Cowie, Catherine C.
影响因子：
120.7
作者：
Dabelea, Dana;Mayer-Davis, Elizabeth J.;Saydah, Sharon;Imperatore, Giuseppina;Linder, Barbara;Divers, Jasmin;Bell, Ronny;Badaru, Angela;Talton, Jennifer W.;Crume, Tessa;Liese, Angela D.;Merchant, Anwar T.;Lawrence, Jean M.;Reynolds, Kristi;Dolan, Lawrence;Liu, Lenna L.;Hamman, Richard F.
通讯作者：
Hamman, Richard F.