Differentiation between vergence and saccadic functional activity within the human frontal eye fields and midbrain revealed through fMRI.
Differentiation between vergence and saccadic functional activity within the human frontal eye fields and midbrain revealed through fMRI.
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DOI：
10.1371/journal.pone.0025866
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Alvarez TL
中科院分区：
文献类型：
--
作者：
Alkan Y;Biswal BB;Alvarez TL
眼动研究传统上只研究眼跳和/或会聚眼动，方法是将这些系统隔离在实验室环境中。虽然眼球跳动的神经关联已经建立，但很少有研究使用fMRI来量化眼球运动的功能活动。这项研究绘制了集中眼球运动的神经基础图，并将它们与眼跳进行比较，以阐明这些系统之间的空间共性和差异。刺激以区块设计呈现，“关”刺激是持续注视，而“开”刺激是随机聚焦或眼球跳动。用3T扫描仪采集数据。一般线性模型(GLM)与集群大小结合使用来确定显著活跃区域。对眼跳和眼跳功能活动之间的GLMβ权重系数进行配对t检验，以检验除了共享神经底物外，眼跳和眼跳刺激将具有空间差异的假设。分离的功能激活在额眼视野内观察到，其中来自集中任务的部分功能活动位于扫视功能活动的前面(z>；2.3；p<；0.03)。中脑中的一个区域与聚光的实验设计显著相关，但与眼跳数据集无关。在以下感兴趣区也观察到类似的功能激活：补充眼区、背外侧前额叶皮质、腹侧前额叶皮质、顶内外侧区、楔形核、楔前核、前扣带回和后扣带回，以及小脑蛔部。通过分析配对t检验(p>；0.2)的Beta权重，这些区域的功能活动在聚光和眼跳数据集之间没有区别。功能磁共振成像可以阐明前部眼野和中脑的投射神经基质和眼跳神经基质的差异。
Eye movement research has traditionally studied solely saccade and/or vergence eye movements by isolating these systems within a laboratory setting. While the neural correlates of saccadic eye movements are established, few studies have quantified the functional activity of vergence eye movements using fMRI. This study mapped the neural substrates of vergence eye movements and compared them to saccades to elucidate the spatial commonality and differentiation between these systems. The stimulus was presented in a block design where the ‘off’ stimulus was a sustained fixation and the ‘on’ stimulus was random vergence or saccadic eye movements. Data were collected with a 3T scanner. A general linear model (GLM) was used in conjunction with cluster size to determine significantly active regions. A paired t-test of the GLM beta weight coefficients was computed between the saccade and vergence functional activities to test the hypothesis that vergence and saccadic stimulation would have spatial differentiation in addition to shared neural substrates. Segregated functional activation was observed within the frontal eye fields where a portion of the functional activity from the vergence task was located anterior to the saccadic functional activity (z>2.3; p<0.03). An area within the midbrain was significantly correlated with the experimental design for the vergence but not the saccade data set. Similar functional activation was observed within the following regions of interest: the supplementary eye field, dorsolateral prefrontal cortex, ventral lateral prefrontal cortex, lateral intraparietal area, cuneus, precuneus, anterior and posterior cingulates, and cerebellar vermis. The functional activity from these regions was not different between the vergence and saccade data sets assessed by analyzing the beta weights of the paired t-test (p>0.2). Functional MRI can elucidate the differences between the vergence and saccade neural substrates within the frontal eye fields and midbrain.
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影响因子：
13.9
作者：
Bisley JW;Goldberg ME
通讯作者：
Goldberg ME
DOI：
10.1098/rspb.1989.0031
发表时间：
1989-05-22
期刊：
PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
ERKELENS, CJ;STEINMAN, RM;COLLEWIJN, H
通讯作者：
COLLEWIJN, H
影响因子：
2.5
作者：
Busettini, C;Mays, LE
通讯作者：
Mays, LE
影响因子：
4.4
作者：
Biswal, Bharat;Kunwar, Pratap;Natelson, Benjamin H.
通讯作者：
Natelson, Benjamin H.
影响因子：
5.5
作者：
ENRIGHT, JT
通讯作者：
ENRIGHT, JT