Respiratory Syncytial Virus (RSV)-Specific Antibodies in Pregnant Women and Subsequent Risk of RSV Hospitalization in Young Infants.
Respiratory Syncytial Virus (RSV)-Specific Antibodies in Pregnant Women and Subsequent Risk of RSV Hospitalization in Young Infants.
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DOI：
10.1093/infdis/jiab315
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发表时间：
2022-04-01
期刊：
影响因子：
--
通讯作者：
Saxén H
中科院分区：
文献类型：
--
作者：
Koivisto K;Nieminen T;Mejias A;Capella Gonzalez C;Ye F;Mertz S;Peeples M;Ramilo O;Saxén H
呼吸道合胞病毒（RSV）的融合(F)糖蛋白是主要的中和抗原，针对F前构象的抗体具有最强的中和活性。本研究旨在评估母体抗f前、f后和G糖蛋白抗体滴度与儿童婴儿期早期发生严重RSV细支气管炎风险的相关性。我们确定了2015年12月至2016年3月期间因RSV细支气管炎住院的健康足月婴儿<3个月。我们测量了这些住院婴儿的母亲（n = 94）在怀孕9-12周获得的母体血清中对f前、f后和G蛋白的IgG抗体滴度，并将其与未住院婴儿的对照孕妇（n = 130）的血清抗体滴度进行了比较。所有母体样本（n = 224）均检测到f前抗体。呼吸道合胞病毒毛细支气管炎住院患儿母亲的前f抗体滴度明显低于未住院患儿母亲(23.9[范围（或抗体滴度范围），1.4-273.7]μ g/L vs 30.6[范围，3.4-220.0]μ g/L；p = .0026)。在住院和非住院婴儿之间，母体f和G抗体滴度无显著差异。我们的研究结果表明，母体前f抗体是为婴儿提供免疫保护的基础。呼吸道合胞病毒（RSV）毛细支气管炎住院的3个月以下婴儿的母亲血清免疫球蛋白抗体滴度低于未住院的年龄匹配对照婴儿的母亲血清样本。
The fusion (F) glycoprotein of respiratory syncytial virus (RSV) represents the major neutralizing antigen, and antibodies against the pre-F conformation have the most potent neutralizing activity. This study aimed to assess the correlation between maternal antibody titers against the pre-F, post-F, and G glycoproteins and the child’s risk of developing severe RSV bronchiolitis early in infancy. We identified previously healthy term infants <3 months of age hospitalized with RSV bronchiolitis from December 2015 to March 2016. We measured IgG antibody titers to pre-F, post-F, and G proteins in maternal sera obtained at 9–12 weeks of pregnancy of these hospitalized infants’ mothers (n = 94) and compared them with serum antibody titers of control pregnant mothers (n = 130) whose children were not hospitalized. All maternal samples (n = 224) had detectable pre-F antibodies. Pre-F antibody titers were significantly lower in mothers whose infants were hospitalized with RSV bronchiolitis compared with those mothers whose infants were not hospitalized (23.9 [range (or antibody titer range), 1.4–273.7] µg/L vs 30.6 [XXX, 3.4–220.0] µg/L; P = .0026). There were no significant differences in maternal post-F and G antibody titers between hospitalized and nonhospitalized infants. Our findings indicate that maternal pre-F antibodies are fundamental for providing immune protection to the infant. Maternal serum immunoglobulin antibody titers directed to respiratory syncytial virus (RSV) pre-F glycoprotein were lower in infants less than 3 months of age hospitalized with RSV bronchiolitis than in maternal serum samples of age-matched control infants who were not hospitalized.
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DOI：
10.1093/cid/ciaa648
发表时间：
2021-12-06
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Buchwald AG;Graham BS;Traore A;Haidara FC;Chen M;Morabito K;Lin BC;Sow SO;Levine MM;Pasetti MF;Tapia MD
通讯作者：
Tapia MD
DOI：
10.1126/science.1234914
发表时间：
2013-05-31
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
McLellan JS;Chen M;Leung S;Graepel KW;Du X;Yang Y;Zhou T;Baxa U;Yasuda E;Beaumont T;Kumar A;Modjarrad K;Zheng Z;Zhao M;Xia N;Kwong PD;Graham BS
通讯作者：
Graham BS
影响因子：
6.4
作者：
Hause, Anne M.;Avadhanula, Vasanthi;Piedra, Pedro A.
通讯作者：
Piedra, Pedro A.
影响因子：
6.4
作者：
Capella, Cristina;Chaiwatpongsakorn, Supranee;Peeples, Mark E.
通讯作者：
Peeples, Mark E.
影响因子：
5.5
作者：
Mejias, Asuncion;Garcia-Maurino, Cristina;Ramilo, Octavio
通讯作者：
Ramilo, Octavio